ArticleJournal of molecular histology2016
Odontoblastic inductive potential of epithelial cells derived from human deciduous dental pulp.
Article in Journal of molecular histology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 21 citations in OpenAlex.
- Next-Generation Strategies for Enamel Repair and Regeneration: Advances in Biomaterials and Translational Challenges.Tissue engineering and regenerative medicine · 2025Review
- Human Primary Odontoblast-like Cell Cultures-A Focused Review Regarding Cell Characterization.Journal of clinical medicine · 2022Review
- Functional expression of TRPA1 channel, TRPV1 channel and TMEM100 in human odontoblasts.Journal of molecular histology · 2021Article
- Scaffold-based developmental tissue engineering strategies for ectodermal organ regeneration.Materials today. Bio · 2021Review
- Differentiation and Establishment of Dental Epithelial-Like Stem Cells Derived from Human ESCs and iPSCs.International journal of molecular sciences · 2020Article
- Tumor Necrosis Factor-α Regulates the TRPA1 Expression in Human Odontoblast-Like Cells.Journal of pain research · 2020Article
- Dentinogenesis and Tooth-Alveolar Bone Complex Defects inStem cells and development · 2019Article
- Constitutive activation of β-catenin in ameloblasts leads to incisor enamel hypomineralization.Journal of molecular histology · 2018Article
- Methylation of Cdkn1c may be involved in the regulation of tooth development through cell cycle inhibition.Journal of molecular histology · 2018Article
- Mouse embryonic fibroblast (MEF)/BMP4-conditioned medium enhanced multipotency of human dental pulp cells.Journal of molecular histology · 2018Article
- Changes of mitochondrial respiratory function during odontogenic differentiation of rat dental papilla cells.Journal of molecular histology · 2018Article
- Blockade of LGR4 inhibits proliferation and odonto/osteogenic differentiation of stem cells from apical papillae.Journal of molecular histology · 2017Article
- Expression and distribution of three transient receptor potential vanilloid(TRPV) channel proteins in human odontoblast-like cells.Journal of molecular histology · 2017Article
- Inhibition of chondroitin sulfate glycosaminoglycans incorporation affected odontoblast differentiation in cultured embryonic mouse molars.Journal of molecular histology · 2017Article
- Hyperlipidemia induced by high-fat diet enhances dentin formation and delays dentin mineralization in mouse incisor.Journal of molecular histology · 2016Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For the dentin regeneration, dental epithelial cells are indispensible and must possess odontoblastic induction capability. Epithelial cell-like stem cells were recently identified in human deciduous dental pulp (DPESCs). However, their cellular characteristics remain poorly defined. The purpose of this study was to characterize DPESCs compared to HAT-7 ameloblastic cells. Expression levels of ameloblast-specific markers [odontogenic ameloblast-associated protein (Odam), matrix metalloproteinase (Mmp)-20, amelogenin, and ameloblastin] were detected in DPESCs. Co-culturing odontoblastic MDPC-23 cells with DPESCs increased expression of odontoblast differentiation markers (Dmp1 and Dspp) from days 4 to 10, while the expression of bone sialoprotein rapidly decreased. MDPC-23 cells cultured in DPESC-conditioned medium (CM) showed increased Dspp promoter activity compared with control MDPC-23 cultures. Mineralization was first observed in the CM groups from day 4 and proceeded rapidly until day 14, whereas mineralized nodules were found from day 7 in control media-cultured cells. In conclusion, DPESCs in human deciduous pulp possess ameloblast-like characteristics and differentiation properties, and substances derived from DPESCs promote odontoblastic differentiation. Thus, our results indicate that DPESCs can be a realistic epithelial source for use in odontoblastic induction and dentin formation of dental mesenchymal cells.
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