ArticleScientific reports2016
Regiospecific synthesis of prenylated flavonoids by a prenyltransferase cloned from Fusarium oxysporum.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 25 citations in OpenAlex.
- Prenylation of Flavanones by an Aromatic Prenyltransferase fromMolecules (Basel, Switzerland) · 2025Article
- Heterologous Biosynthesis of Prenylflavonoids inACS omega · 2025Article
- Phytochemistry and pharmacology of natural prenylated flavonoids.Archives of pharmacal research · 2023Review
- Challenges in the Heterologous Production of Furanocoumarins inMolecules (Basel, Switzerland) · 2022Article
- Prenylated Flavonoids with Potential Antimicrobial Activity: Synthesis, Biological Activity, and In Silico Study.International journal of molecular sciences · 2021Article
- Synthesis of Novel Stilbene-Coumarin Derivatives and Antifungal Screening ofAntibiotics (Basel, Switzerland) · 2020Article
- Enzymatic studies on aromatic prenyltransferases.Journal of natural medicines · 2020Review
- Synthesis of prenylated flavonols and their potents as estrogen receptor modulator.Scientific reports · 2017Article
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Due to their impressive pharmaceutical activities and safety, prenylated flavonoids have a high potent to be applied as medicines and nutraceuticals. Biocatalysis is an effective technique to synthesize prenylated flavonoids. The major concern of this technique is that the microbe-derived prenyltransferases usually have poor regiospecificity and generate multiple prenylated products. In this work, a highly regiospecific prenyltransferase (FoPT1) was found from Fusarium oxysporum. It could recognize apigenin, naringenin, genistein, dihydrogenistein, kampferol, luteolin and hesperetin as substrates, and only 6-C-prenylated flavonoids were detected as the products. The catalytic efficiency of FoPT1 on flavonoids was in a decreasing order with hesperetin >naringenin >apigenin >genistein >luteolin >dihydrogenistein >kaempferol. Chalcones, flavanols and stilbenes were not active when acting as the substrates. 5,7-Dihydroxy and 4-carbonyl groups of flavonid were required for the catalysis. 2,3-Alkenyl was beneficial to the catalysis whereas 3-hydroxy impaired the prenylation reaction. Docking studies simulated the prenyl transfer reaction of FoPT1. E186 was involved in the formation of prenyl carbonium ion. E98, F89, F182, Y197 and E246 positioned apigenin for catalysis.
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