ArticleMalaria journal2016
Genomic variation in two gametocyte non-producing Plasmodium falciparum clonal lines.
Article in Malaria journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Modest heterologous protection after Plasmodium falciparum sporozoite immunization: a double-blind randomized controlled clinical trial.BMC medicine · 2017Trial
- Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum.Microbiology spectrum · 2023Article
- Genetic diversity ofLancet regional health. Americas · 2023Article
- Revisiting the malaria hypothesis: accounting for polygenicity and pleiotropy.Trends in parasitology · 2022Review
- Novel insights from the Plasmodium falciparum sporozoite-specific proteome by probabilistic integration of 26 studies.PLoS computational biology · 2021Article
- Selective whole genome amplification of Plasmodium malariae DNA from clinical samples reveals insights into population structure.Scientific reports · 2020Article
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- Article
- ApiAP2 Transcription Factors in Apicomplexan Parasites.Pathogens (Basel, Switzerland) · 2019Review
- Methylene blue induced morphological deformations in Plasmodium falciparum gametocytes: implications for transmission-blocking.Malaria journal · 2018Article
- Plasmodium falciparum parasites with histidine-rich protein 2 (pfhrp2) and pfhrp3 gene deletions in two endemic regions of Kenya.Scientific reports · 2017Article
- Repetitive sequences in malaria parasite proteins.FEMS microbiology reviews · 2017Review
- Analysis of nuclear and organellar genomes of Plasmodium knowlesi in humans reveals ancient population structure and recent recombination among host-specific subpopulations.PLoS genetics · 2017Article
- Genomic variation in Plasmodium vivax malaria reveals regions under selective pressure.PloS one · 2017Article
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Authors and funding
14 authors.
Funding
Abstract
backgroundTransmission of the malaria parasite Plasmodium falciparum from humans to the mosquito vector requires differentiation of a sub-population of asexual forms replicating within red blood cells into non-dividing male and female gametocytes. The nature of the molecular mechanism underlying this key differentiation event required for malaria transmission is not fully understood.
methodsWhole genome sequencing was used to examine the genomic diversity of the gametocyte non-producing 3D7-derived lines F12 and A4. These lines were used in the recent detection of the PF3D7_1222600 locus (encoding PfAP2-G), which acts as a genetic master switch that triggers gametocyte development.
resultsThe evolutionary changes from the 3D7 parental strain through its derivatives F12 (culture-passage derived cloned line) and A4 (transgenic cloned line) were identified. The genetic differences including the formation of chimeric var genes are presented.
conclusionA genomics resource is provided for the further study of gametocytogenesis or other phenotypes using these parasite lines.
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