Evidence map›Paper›PMID 27098459›Full record

ReviewThe Journal of physiology2016

Translational neurocardiology: preclinical models and cardioneural integrative aspects.

J L Ardell, M C Andresen, J A Armour, G E Billman, P-S Chen, R D Foreman, N Herring, D S O'Leary, H N Sabbah, H D Schultz and 2 more

Open access · greenAbstract readReview
In one paragraph

Review in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 1 pooled it
12.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 1 synthesis or guideline pooled it, 172 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Single-Electrode, Bidirectional Control of Heart Rate via Vagus Nerve Modulation in Rat Model.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2026
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  8. Review
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  16. Review
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  18. Review
  19. Cardiac Neuroanatomy and Fundamentals of Neurocardiology.Cardiac electrophysiology clinics · 2024
    Review
  20. Review

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 3 countries.

J L ArdellUniversity of California - Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, CA, USA.
M C AndresenDepartment of Physiology and Pharmacology, Oregon Health and Science University, Portland, OR, USA.
J A ArmourUniversity of California - Los Angeles (UCLA) Cardiac Arrhythmia Center, David Geffen School of Medicine, Los Angeles, CA, USA.
G E BillmanDepartment of Physiology and Cell Biology, The Ohio State University, Columbus, OH, USA.
P-S ChenThe Krannert Institute of Cardiology and Division of Cardiology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA.
R D ForemanDepartment of Physiology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA.
N HerringDepartment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK.
D S O'LearyDepartment of Physiology, Wayne State University, Detroit, MI, USA.
H N SabbahDepartment of Medicine, Henry Ford Hospital, Detroit, MI, USA.
H D SchultzCellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
K SunagawaDepartment of Cardiovascular Medicine, Kyushu University, Fukuoka, Japan.
I H ZuckerCellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, USA.
University of California, Los Angeles · USUniversity of Nebraska Medical Center · USHenry Ford Hospital · USIndiana University School of MedicineKyushu University · JPOregon Health & Science University · USThe Ohio State University · USUniversity of Oklahoma Health Sciences Center · USUniversity of Oxford · GBWayne State University · US

Funding

The Role of Excitatory Input into the PVN on Increased Sympathetic Drive in HeartP01HL062222 · NHLBI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SCHULTZ, HAROLD D · 1999 to 2019
$32.2M
WAVE DYNAMICS IN NORMAL AND DISEASED RABBIT HEARTSP01HL078931 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHEN, PENG-SHENG · 2005 to 2015
$20.7M
Substrate Selection and Oxidative Stress in Heart FailureP01HL074237 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI STANLEY, WILLIAM C · 2003 to 2013
$19.9M
BLOOD PRESSURE CONTROL DURING EXERCISE IN HEART FAILURER01HL055473 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 1996 to 2024
$9.8M
Thoracic Veins and Sustained Atrial FibrillationR01HL071140 · NHLBI · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI CHEN, PENG-SHENG · 2002 to 2014
$4.7M
Myocardial Ischemia Remodels the Cardiac Nervous SystemR01HL071830 · NHLBI · EAST TENNESSEE STATE UNIVERSITY · PI ARDELL, JEFFREY L · 2005 to 2013
$2.8M
Mechanisms Mediating Enhanced Sympatho-Activation During Exercise in HypertensionR01HL126706 · NHLBI · WAYNE STATE UNIVERSITY · PI O'LEARY, DONAL S · 2016 to 2019
$2.2M
Dietary Omega-3 Fatty Acids and Sudden Cardiac DeathR01HL086700 · NHLBI · OHIO STATE UNIVERSITY · PI BILLMAN, GEORGE EDWARD · 2007 to 2010
$1.9M
Central TRPV1 in Cardiovascular RegulationR01HL105703 · NHLBI · OREGON HEALTH & SCIENCE UNIVERSITY · PI ANDRESEN, MICHAEL CHRISTIAN · 2011 to 2014
$1.5M
SENSORY AND RESPIRATORY INTEGRATION IN C1-C2 SPINAL CORDR01NS035471 · NINDS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI FOREMAN, ROBERT D · 1996 to 2006
$1.4M
Spinal hierarchy and noxious cardiac sensory processingR01HL075524 · NHLBI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI FOREMAN, ROBERT D · 2004 to 2007
$1.4M
Distributed electrode system for high-fidelity cardio-neural mappingU18EB021799 · NIBIB · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARDELL, JEFFREY L, KIPKE, DARYL R · 2015 to 2017
$640k
British Heart Foundation FS/15/8/31155NHLBI NIH HHS P01 HL062222NHLBI NIH HHS P01 HL074237NHLBI NIH HHS P01 HL078931NHLBI NIH HHS R01 HL055473NHLBI NIH HHS R01 HL071140NHLBI NIH HHS R01 HL071830NHLBI NIH HHS R01 HL075524NHLBI NIH HHS R01 HL086700NHLBI NIH HHS R01 HL105703NHLBI NIH HHS R01 HL126706NHLBI NIH HHS R41 HL124741NIBIB NIH HHS U18 EB021799NINDS NIH HHS R01 NS035471
6 · The paper itself

Abstract

Neuronal elements distributed throughout the cardiac nervous system, from the level of the insular cortex to the intrinsic cardiac nervous system, are in constant communication with one another to ensure that cardiac output matches the dynamic process of regional blood flow demand. Neural elements in their various 'levels' become differentially recruited in the transduction of sensory inputs arising from the heart, major vessels, other visceral organs and somatic structures to optimize neuronal coordination of regional cardiac function. This White Paper will review the relevant aspects of the structural and functional organization for autonomic control of the heart in normal conditions, how these systems remodel/adapt during cardiac disease, and finally how such knowledge can be leveraged in the evolving realm of autonomic regulation therapy for cardiac therapeutics.

Indexed as

AnimalsAutonomic Nervous SystemCardiovascular DiseasesHeartHumans

Identifiers

PMID27098459
PMCPMC4945715
OpenAlexW2340401086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.