Trial reportJournal of clinical hypertension (Greenwich, Conn.)2016
Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin-A Randomized Placebo-Controlled Trial.
Trial report in Journal of clinical hypertension (Greenwich, Conn.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 4 syntheses or guidelines pooled it, 43 citations in OpenAlex.
- Bone and mineral metabolism in patients with primary aldosteronism: A systematic review and meta-analysis.Frontiers in endocrinology · 2022Pooled it
- Vitamin D and adrenal gland: Myth or reality? A systematic review.Frontiers in endocrinology · 2022Pooled it
- Guideline
- Non-skeletal health effects of vitamin D supplementation: A systematic review on findings from meta-analyses summarizing trial data.PloS one · 2017Pooled it
- Effects of Vitamin D Supplementation on Cardiovascular and Glycemic Biomarkers.Journal of the American Heart Association · 2021Trial
- Effects of vitamin D supplementation on FGF23: a randomized-controlled trial.European journal of nutrition · 2019Trial
- Trial
- Effects of Vitamin D Supplementation on IGF-1 and Calcitriol: A Randomized-Controlled Trial.Nutrients · 2017Trial
- Effects of Vitamin D Supplementation on Plasma Aldosterone and Renin-A Randomized Placebo-Controlled Trial.Journal of clinical hypertension (Greenwich, Conn.) · 2016Trial
- A randomized intervention study to evaluate the effect of calcitriol therapy on the renin-angiotensin system in diabetes.Journal of the renin-angiotensin-aldosterone system : JRAASTrial
- Association between vitamin D deficiency and adrenal gland, kidney function, indicators related to cardiovascular function in hypertensive patients.Frontiers in nutrition · 2026Article
- Association Between Nutrients and Cardiovascular Diseases.Current cardiology reviews · 2024Review
- Article
- Latest Knowledge on the Role of Vitamin D in Hypertension.International journal of molecular sciences · 2023Review
- Relationship between selection of dosage forms of vitamin D receptor activators and short-term survival of patients on hemodialysis.Renal failure · 2021Article
- NO Synthesis Markers are Not Significantly Associated with Blood Pressure and Endothelial Dysfunction in Patients with Arterial Hypertension: A Cross-Sectional Study.Journal of clinical medicine · 2020Article
- Determinants of Vitamin D Supplementation among Individuals with Type 1 Diabetes.International journal of environmental research and public health · 2020Article
- Nutritional assessment among adult patients with suspected or confirmed active tuberculosis disease in rural India.PloS one · 2020Article
- Vitamin D deficiency is an independent predictor of mortality in patients with chronic heart failure.European journal of nutrition · 2019Article
- Postmenopausal osteoporosis is associated with elevated aldosterone/renin ratio.Journal of human hypertension · 2018Article
Corrections and comments
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Authors and funding
14 authors at 3 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increasing evidence describes a possible interplay between vitamin D insufficiency with increased aldosterone. The authors sought to evaluate the effect of vitamin D supplementation on plasma aldosterone concentration (PAC) in patients with hypertension and 25-hydroxyvitamin D[25(OH)D] insufficiency. The Styrian Vitamin D Hypertension Trial was a single-center, double-blind, placebo-controlled randomized clinical trial conducted from 2011 to 2014. Two hundred patients with arterial hypertension and 25(OH)D levels <30 ng/mL were enrolled. Study participants were randomized to receive either 2800 IU of vitamin D3 or placebo. The present investigation is a post hoc analysis using analysis of covariance adjusting for baseline differences. A total of 188 participants (mean±standard deviation age, 60.1±11.3 years; 47% women; 25(OH)D, 21.2±5.6 ng/mL) completed the trial. Mean differences between baseline and follow-up PAC in the control and intervention arm were +3.3 ng/dL and +0.9 ng/dL, respectively (P=.04). The findings indicate that vitamin D3 supplementation significantly decreases PAC in patients with arterial hypertension and 25(OH)D insufficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.