ArticleJournal of assisted reproduction and genetics2016
Comparison of differences in development potentials between frozen-thawed D5 and D6 blastocysts and their relationship with pregnancy outcomes.
Article in Journal of assisted reproduction and genetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.
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Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Day 5 versus Day 6 blastocyst transfers: a systematic review and meta-analysis of clinical outcomes.Human reproduction (Oxford, England) · 2019Pooled it
- Increased live births after day 5 versus day 6 transfers of vitrified-warmed blastocysts.Journal of assisted reproduction and genetics · 2018Trial
- Interaction between progesterone exposure duration and blastocyst expansion stage on live birth following frozen-thawed transfer of day-6 blastocysts.Frontiers in endocrinology · 2026Article
- Effect of progesterone timing on live birth rates in day-6 blastocyst frozen-thawed embryo transfer cycles: a randomized controlled trial.Human reproduction open · 2026Article
- Effect of day 3 cell number on the pregnancy and neonatal outcomes of vitrified-warmed single blastocyst transfer.European journal of medical research · 2025Article
- Day 6 vitrified blastocyst transfer on day 5 vs. day 6 of progesterone shows similar outcomes in HRT-FET cycles: a cohort study.Scientific reports · 2025Article
- Delayed blastulation and pregnancy outcomes in single frozen-thawed euploid blastocyst transfer.Frontiers in endocrinology · 2025Article
- Evaluation of day 5 versus day 6 blastocyst biopsy in preimplantation genetic testing: clinical and neonatal outcomes.Frontiers in endocrinology · 2025Article
- Impact of Transfer Timing on Day-6 Blastocyst Pregnancy Outcomes in HRT Cycles of 2021-2024.International journal of general medicine · 2025Article
- Effect of day 5 or 6 blastocyst embryo transfer on pregnancy outcomes in euthyroid women undergoing IVF: A single centre retrospective cohort.JBRA assisted reproduction · 2024Article
- Is a day 7 blastocyst predictive of the reproductive potential of sibling day 5 and day 6 blastocysts?Journal of assisted reproduction and genetics · 2024Article
- Novel Time-Lapse Parameters Correlate with Embryo Ploidy and Suggest an Improvement in Non-Invasive Embryo Selection.Journal of clinical medicine · 2023Article
- Pregnancy Outcomes for Day 5 Versus Day 6 Single Frozen-thawed Blastocyst Transfer with Different Qualities of Embryos: A Large Matched-cohort Study.Current medical science · 2023Article
- The pregnancy outcomes of day-5 poor-quality and day-6 high-quality blastocysts in single blastocyst transfer cycles.Clinical and experimental reproductive medicine · 2023Article
- Comparison of aneuploidy rate in spontaneous abortion chorionic villus between D6 and D5 thawed-frozen blastocyst transfer.BMC pregnancy and childbirth · 2023Article
- Comparison of clinical outcomes for different morphological scores of D5 and D6 blastocysts in the frozen-thawed cycle.BMC pregnancy and childbirth · 2023Article
- No advantage of single day 6 good-quality blastocyst transfer versus single day 5 poor-quality blastocyst transfer in frozen-thawed cycles stratified by age: a retrospective study.BMC pregnancy and childbirth · 2023Article
- Comparing Day 5 versus Day 6 euploid blastocyst in frozen embryo transfer and developing a predictive model for optimizing outcomes: a retrospective cohort study.Frontiers in endocrinology · 2023Article
- D6 high-quality expanded blastocysts and D5 expanded blastocysts have similar pregnancy and perinatal outcomes following single frozen blastocyst transfer.Frontiers in endocrinology · 2023Article
- Comparison of clinical outcomes of frozen-thawed D5 and D6 blastocysts undergoing preimplantation genetic testing.Journal of translational medicine · 2022Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWhether there are differences in the pregnancy outcomes of blastocysts cryopreserved during different developmental stages remains under debate because the results among studies are inconsistent. We analyzed blastocyst quality and pregnancy outcomes by considering blastocyst euploidy and investigated the differences in the development potential between blastocysts of different developmental stages (frozen-thawed day 5 [D5] and day 6 [D6] cycles) and their relationship with clinical pregnancy outcomes.
methodsIn total, 1374 D5 and 255 D6 frozen-thawed blastocyst transfer cycles were retrospectively analyzed. Additionally, the chromosome euploidy and clinical pregnancy rates of 237 blastocysts from 50 pre-implantation genetic diagnosis (PGS) cycles were statistically analyzed. The corresponding euploidy rate and pregnancy outcomes of the D5 and D6 blastocyst transfers were also compared.
resultsThe clinical pregnancy rate (47.2 vs 40.0 %; P = 0.04) and implantation rate (34.2 vs 28.8 %; P = 0.03) of the D5 blastocysts were higher than were those of the D6 blastocysts. However, the clinical pregnancy rate (52.4 vs 52.6 %; P = 0.97) and implantation rate (38.9 vs 35.6 %; P = 0.39) of the high-quality D5 blastocysts did not significantly differ from those of the high-quality D6 blastocysts. Analysis of blastocyst euploidy in 237 blastocysts examined in 50 PGS cycles showed that the euploidy rates of the D5 and D6 blastocysts were both 48.1 % (P = 0.99). The clinical pregnancy rate of the D5 blastocysts (48.5 vs 17.6 %; P = 0.03) was higher than that of the D6 blastocysts. The euploidy rates (55.2 vs 55.3 %; P = 0.99) and clinical pregnancy rates (60.0 vs 42.9 %; P = 0.77) of the high-quality D5 and D6 blastocysts did not differ. The euploidy rate (55.3 vs 41.5 %, P = 0.03) and clinical pregnancy rate (54.5 vs 25.0 %, P = 0.03) of the high-quality blastocysts were higher than were those of the poor-quality blastocysts.
conclusionsThe euploidy rates between the D5 and D6 blastocysts did not differ. High-quality D6 blastocysts in frozen-thawed cycles had similar developmental potential and pregnancy outcomes compared to those of high-quality D5 blastocysts. The quality of the blastocysts was an important factor that affected the pregnancy outcomes of the frozen-thawed cycles.
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