ArticlePloS one2016
Magnetic Resonance Imaging of Cerebral Aspergillosis: Imaging and Pathological Correlations.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 77 citations in OpenAlex.
- Central Nervous System Aspergillosis: Advances in Diagnosis, Therapeutics, and Multidisciplinary Management (2026 Update).Mycoses · 2026Review
- Clinical characteristics, diagnosis, and management of central nervous system aspergillosis in children: a single-center experience.BMC infectious diseases · 2026Article
- Cerebral Aspergillosis: Diagnostic Challenges, Therapeutic Strategies, and Future Research.CNS drugs · 2026Review
- Angiographically occult catastrophe: A rare case of aspergillus-induced subarachnoid hemorrhage without mycotic aneurysms following apparent bacterial abscess resolution.Medical mycology case reports · 2025Article
- CNS Aspergillosis: A Downside of Corticosteroid Use.Cureus · 2024Article
- Aneurysm, meningitis, and subarachnoid hemorrhage secondary to intracranialQuantitative imaging in medicine and surgery · 2024Article
- Evolution of neuroimaging findings in angioinvasive cerebral aspergillosis in a pediatric patient with leukemia during long-term observation.BMC infectious diseases · 2023Article
- Imaging Findings in Aspergillosis: From Head to Toe.Mycopathologia · 2023Review
- Invasive Fungal Infections after Liver Transplantation.Journal of clinical medicine · 2023Review
- Infection due to Aspergillus flavus and Rhizopus oryzae complex in a patient with diabetes mellitusBiomedica : revista del Instituto Nacional de Salud · 2023Article
- Successful Multimodal Therapy with Intracerebral Liposomal Amphotericin B and Systemic High-Dose Isavuconazole in Proven Disseminated Aspergillosis.Journal of fungi (Basel, Switzerland) · 2023Article
- Cerebral mucormycosis: neuroimaging findings and histopathological correlation.Journal of neurology · 2022Article
- Invasive sinus aspergillosis with mycotic aneurysm of the vertebral artery and subarachnoid hemorrhage - Case report.Radiology case reports · 2021Article
- Article
- Fatal disseminated aspergillosis in an immunocompetent patient with COVID-19 due to Aspergillus ochraceus.Journal de mycologie medicale · 2021Article
- Central nervous system aspergillosis in immunocompetent patients: Case series and literature review.Medicine · 2020Observational
- Invasive Mold Infection of the Central Nervous System in Immunocompromised Children.Journal of fungi (Basel, Switzerland) · 2020Article
- MR Target Sign in Cerebral Aspergillosis.The Neurohospitalist · 2020Article
- Role of Voriconazole in the Management of Invasive Central Nervous System Aspergillosis: A Case Series from a Tertiary Care Centre in India.Journal of fungi (Basel, Switzerland) · 2020Article
- Cerebral and pulmonary aspergillosis, treatment and diagnostic challenges of mixed breakthrough invasive fungal infections: case report study.BMC infectious diseases · 2020Article
Corrections and comments
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Authors and funding
17 authors at 7 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cerebral aspergillosis is associated with a significant morbidity and mortality rate. The imaging data present different patterns and no full consensus exists on typical imaging characteristics of the cerebral lesions. We reviewed MRI findings in 21 patients with cerebral aspergillosis and correlated them to the immune status of the patients and to neuropathological findings when tissue was available. The lesions were characterized by their number, topography, and MRI signal. Dissemination to the brain resulted from direct spread from paranasal sinuses in 8 patients, 6 of them being immunocompetent. Hematogenous dissemination was observed in 13 patients, all were immunosuppressed. In this later group we identified a total of 329 parenchymal abscesses involving the whole brain with a predilection for the corticomedullary junction. More than half the patients had a corpus callosum lesion. Hemorrhagic lesions accounted for 13% and contrast enhancement was observed in 61% of the lesions. Patients with hematogenous dissemination were younger (p = 0.003), had more intracranial lesions (p = 0.0004) and had a higher 12-week mortality rate (p = 0.046) than patients with direct spread from paranasal sinuses. Analysis of 12 aneurysms allowed us to highlight two distinct situations. In case of direct spread from the paranasal sinuses, aneurysms are saccular and located on the proximal artery portions, while the hematogenous dissemination in immunocompromised patients is more frequently associated with distal and fusiform aneurysms. MRI is the exam of choice for cerebral aspergillosis. Number and type of lesions are different according to the mode of dissemination of the infection.
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