ArticleOncotarget2016
Prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma.
Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.
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Who cites it
44 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Prognostic significance of microRNA-135 in patients with digestive system cancers: a systematic review and meta-analysis.Bioscience reports · 2019Pooled it
- The Prognostic Value of the Advanced Lung Cancer Inflammation Index on Disease-Free Survival in Patients with Gastric Cancer Receiving Neoadjuvant Chemotherapy.Journal of clinical medicine · 2026Article
- A novel combined model integrating collagen properties, radiomics and clinical data to predict gastric cancer prognosis.Frontiers in oncology · 2026Article
- Combined albumin and CEA improve prognostic prediction in resectable gastric cancer.Scientific reports · 2025Article
- Prognostic value of [European journal of nuclear medicine and molecular imaging · 2025Article
- Nutritional and Biochemical Outcomes After Total Versus Subtotal Gastrectomy: Insights into Early Postoperative Prognosis.Nutrients · 2025Article
- Efficacy and safety of XELOX combined with neoadjuvant radiotherapy versus neoadjuvant chemotherapy in locally advanced gastric cancer.BMC cancer · 2025Article
- The combination of CA125, CA199, CEA, and AFP is an effective diagnostic biomarker for gastric cancer in elderly individuals.World journal of surgical oncology · 2025Article
- Identifying the signature of NAD+ metabolism-related genes for immunotherapy of gastric cancer.Heliyon · 2024Article
- Lipid levels and insulin resistance markers in gastric cancer patients: diagnostic and prognostic significance.BMC gastroenterology · 2024Article
- Combination of clinical and spectral-CT iodine concentration for predicting liver metastasis in gastric cancer: a preliminary study.Abdominal radiology (New York) · 2024Article
- PPIH acts as a potential predictive biomarker for patients with common solid tumors.BMC cancer · 2024Article
- Prognostic Impact of Perioperative CA125 Status in Gastric Cancer Based on New Cutoff Values.Cureus · 2024Article
- Combined Use of Tumor Markers in Gastric Cancer: A Novel Method with Promising Prognostic Accuracy and Practicality.Annals of surgical oncology · 2023Article
- Circulating Proteins as Diagnostic Markers in Gastric Cancer.International journal of molecular sciences · 2023Review
- Prognostic significance of post-preoperative tumor markers increments in patients with non-metastatic gastric cancer.Journal of cancer research and clinical oncology · 2023Article
- Article
- Application of serum gastric function markers and digestive tumor indices to the diagnosis of early gastric cancer and precancerous lesions.Saudi medical journal · 2023Article
- Thioredoxin reductase as a novel biomarker for the diagnosis and efficacy prediction of gastrointestinal malignancy: a large-scale, retrospective study.International journal of clinical oncology · 2023Article
- A novel prognostic model to predict OS and DFS of stage II/III gastric adenocarcinoma patients in China.Heliyon · 2022Article
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Authors and funding
13 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prognostic significance of preoperative serum CA125, CA19-9 and CEA in gastric carcinoma (GC) has been widely reported and is still under debate. Here, we evaluated the prognostic significance of preoperative serum CA125, CA19-9 and CEA in patients with GC. 1692 patients with GC who underwent gastrectomy were divided into the training (from January 2005 to December 2011, n = 1024) and the validation (from January 2012 to December 2013, n = 668) cohorts. Positive groups of CA125 (> 13.72 U/ml), CA19-9 (> 23.36 U/ml) and CEA (> 4.28 ng/ml) were significantly associated with more advanced clinicopathological traits and worse outcomes than that of negative groups (all P < 0.01). In Cox regression analysis, tumor size (P < 0.001, P = 0.005), pTNM stage (P < 0.001, P < 0.001) and CA125 (P = 0.026, P = 0.005) were independent prognostic factors both in two cohorts. Nomograms of these two cohorts based on the number of positive serum tumor markers (NPTM) were more accurate in prognostic prediction than TNM stage alone. Our findings suggested that elevated preoperative serum CA125, CA19-9 and CEA were associated with more advanced clinicopathological traits and less favorable outcomes. In addition, CA125 as an independent prognostic factor should be further investigated. Nomogram based on NPTM could accurately predict the prognosis of GC patients.
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