Evidence map›Paper›PMID 27096875›Full record

ArticleActa physiologica (Oxford, England)2017

Increased microvascular permeability in mice lacking Epac1 (Rapgef3).

R K Kopperud, C Brekke Rygh, T V Karlsen, C Krakstad, R Kleppe, E A Hoivik, M Bakke, O Tenstad, F Selheim, Å Lidén and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta physiologica (Oxford, England), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 41 citations in OpenAlex.

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  20. Epac1Acta physiologica (Oxford, England) · 2019
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

17 authors at 4 institutions in 3 countries.

R K KopperudDepartment of Biomedicine, University of Bergen, Bergen, Norway.
C Brekke RyghDepartment of Biomedicine, University of Bergen, Bergen, Norway.
T V KarlsenDepartment of Biomedicine, University of Bergen, Bergen, Norway.
C KrakstadDepartment of Biomedicine, University of Bergen, Bergen, Norway.
R KleppeDepartment of Biomedicine, University of Bergen, Bergen, Norway.
E A HoivikDepartment of Biomedicine, University of Bergen, Bergen, Norway.
M BakkeDepartment of Biomedicine, University of Bergen, Bergen, Norway.
O TenstadDepartment of Biomedicine, University of Bergen, Bergen, Norway.
F SelheimDepartment of Biomedicine, University of Bergen, Bergen, Norway.
Å LidénDepartment of Biomedicine, University of Bergen, Bergen, Norway.
L MadsenDepartment of Biomedicine, University of Bergen, Bergen, Norway.
T PavlinDepartment of Biomedicine, University of Bergen, Bergen, Norway.
T TaxtDepartment of Biomedicine, University of Bergen, Bergen, Norway.
K KristiansenDepartment of Biology, University of Copenhagen, Copenhagen, Denmark.
F-R E CurryDepartment of Physiology and Membrane Biology, School of Medicine, University of California, Davis, CA, USA.
R K ReedDepartment of Biomedicine, University of Bergen, Bergen, Norway.
S O DøskelandDepartment of Biomedicine, University of Bergen, Bergen, Norway.
University of Bergen · NOBerGenBio (Norway) · NOUniversity of California, Davis · USUniversity of Copenhagen · DK

Funding

WATER AND SOLUTE TRANSPORT ACROSS CAPILLARY ENDOTHELIUMR01HL028607 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI CURRY, FITZ-ROY E · 1985 to 2014
$3.9M
TRANSPORT ACROSS CAPILLARY ENDOTHELIUMR37HL028607 · NHLBI · UNIVERSITY OF CALIFORNIA DAVIS · PI CURRY, FITZ-ROY E · 1992 to 2001
$504k
NHLBI NIH HHS R01 HL028607NHLBI NIH HHS R37 HL028607
6 · The paper itself

Abstract

aimMaintenance of the blood and extracellular volume requires tight control of endothelial macromolecule permeability, which is regulated by cAMP signalling. This study probes the role of the cAMP mediators rap guanine nucleotide exchange factor 3 and 4 (Epac1 and Epac2) for in vivo control of microvascular macromolecule permeability under basal conditions.

methodsEpac1

resultsEpac1

conclusionEpac1 exerts a tonic inhibition of in vivo basal microvascular permeability. The loss of this tonic action increases baseline permeability, presumably by reducing the interendothelial permeability resistance. Part of the action of ANP to increase permeability in wild-type microvessels may involve inhibition of the basal Epac1-dependent activity.

Indexed as

AnimalsBlotting, WesternCapillary PermeabilityDisease Models, AnimalFemaleGuanine Nucleotide Exchange FactorsImmunohistochemistryMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, Electron, TransmissionEpac protein, mouseGuanine Nucleotide Exchange FactorsRapgef4 protein, mouseatrial natriuretic peptidecAMPendothelial junctionEpac deletion (mouse)microvascular permeability (in vivo)Rapgef

Identifiers

PMID27096875
PMCPMC5073050
OpenAlexW2338667326

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.