ArticleMolecules (Basel, Switzerland)2016
Eremophilane Sesquiterpenes from a Deep Marine-Derived Fungus, Aspergillus sp. SCSIOW2, Cultivated in the Presence of Epigenetic Modifying Agents.
Article in Molecules (Basel, Switzerland), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Eremophilane-Type Sesquiterpenoids from FungusMolecules (Basel, Switzerland) · 2025Article
- Apium graveolens-associated Aspergillus sp.: metabolomic profiling and anti-MRSA potential supported by in silico studies.Microbial cell factories · 2025Article
- Marine Microorganism Molecules as Potential Anti-Inflammatory Therapeutics.Marine drugs · 2024Review
- A Close View of the Production of Bioactive Fungal Metabolites Mediated by Chromatin Modifiers.Molecules (Basel, Switzerland) · 2024Review
- The Plethora of Microbes with Anti-Inflammatory Activities.International journal of molecular sciences · 2024Review
- Chemical Epigenetic Regulation Secondary Metabolites Derived fromMolecules (Basel, Switzerland) · 2024Article
- Recent Advances in Search of Bioactive Secondary Metabolites from Fungi Triggered by Chemical Epigenetic Modifiers.Journal of fungi (Basel, Switzerland) · 2023Review
- Eremophilane-Type Sesquiterpenes from a Marine-Derived Fungus Penicillium Copticola with Antitumor and Neuroprotective Activities.Marine drugs · 2022Article
- Research Advances of Bioactive Sesquiterpenoids Isolated from Marine-DerivedMolecules (Basel, Switzerland) · 2022Review
- Cryptic Metabolites from Marine-Derived Microorganisms Using OSMAC and Epigenetic Approaches.Marine drugs · 2022Review
- Extremophilic Fungi from Marine Environments: Underexplored Sources of Antitumor, Anti-Infective and Other Biologically Active Agents.Marine drugs · 2022Review
- Epigenetic Modification: A Key Tool for Secondary Metabolite Production in Microorganisms.Frontiers in microbiology · 2022Review
- Novel Harziane Diterpenes from Deep-Sea Sediment FungusMarine drugs · 2021Article
- Article
- Metabolites of Marine Sediment-Derived Fungi: Actual Trends of Biological Activity Studies.Marine drugs · 2021Review
- Review
- Isolation and Characterization of New Anti-Inflammatory and Antioxidant Components from Deep Marine-Derived FungusMarine drugs · 2020Article
- Marine Terpenoids from Polar Latitudes and Their Potential Applications in Biotechnology.Marine drugs · 2020Review
- A Review of Terpenes from Marine-Derived Fungi: 2015-2019.Marine drugs · 2020Review
- Epigenetic Agents Trigger the Production of Bioactive Nucleoside Derivatives and Bisabolane Sesquiterpenes From the Marine-Derived FungusFrontiers in microbiology · 2020Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chemical epigenetic manipulation was applied to a deep marine-derived fungus, Aspergillus sp. SCSIOW2, resulting in significant changes of the secondary metabolites. Three new eremophilane-type sesquiterpenes, dihydrobipolaroxin B (2), dihydrobipolaroxin C (3), and dihydrobipolaroxin D (4), along with one known analogue, dihydrobipolaroxin (1), were isolated from the culture treated with a combination of histone deacetylase inhibitor (suberohydroxamic acid) and DNA methyltransferase inhibitor (5-azacytidine). 1-4 were not produced in the untreated cultures. 2 and 3 might be artificial because 1 could form 2 and 3 spontaneously in water by intracellular acetalization reaction. The absolute configurations of 1 and 2 were assigned based on ECD spectroscopy combined with time-dependent density functional theory calculations. All four compounds exhibited moderate nitric oxide inhibitory activities without cytotoxic effects.
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