ArticlePloS one2016
Osteoclastogenesis in Local Alveolar Bone in Early Decortication-Facilitated Orthodontic Tooth Movement.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Impact of periodontal microRNAs associated with alveolar bone remodeling during orthodontic tooth movement: a randomized clinical trial.Journal of translational medicine · 2024Trial
- Enhancement of Orthodontic Tooth Movement by Oral Administration of Pangasius hypophthalmus Oil: An In Vivo Study.Orthodontics & craniofacial research · 2026Article
- The effect of low-frequency high-intensity ultrasound combined with aspirin on tooth movement in rats.BMC oral health · 2023Article
- Vitamin E enriched diet increases the rate of orthodontic tooth movement.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2022Article
- Exogenous adenosine activates A2A adenosine receptor to inhibit RANKL-induced osteoclastogenesis via AP-1 pathway to facilitate bone repair.Molecular biology reports · 2022Article
- Surgery-First Approach; from Claims to Evidence: A Comprehensive Review.Frontiers in dentistry · 2022Review
- Comparison of the effects of horizontal and vertical micro-osteoperforations on the biological response and tooth movement in rabbits.Korean journal of orthodontics · 2021Article
- Effects of premature contact in maxillary alveolar bone in rats: relationship between experimental analyses and a micro scale FEA computational simulation study.Clinical oral investigations · 2021Article
- Combating Constraints of the Functional Matrix: The Importance of Overcorrection in Pediatric Craniofacial Surgery.Plastic and reconstructive surgery. Global open · 2021Article
- Comparison of tooth movement and biological response resulting from different force magnitudes combined with osteoperforation in rabbits.Journal of applied oral science : revista FOB · 2021Article
- Comparison of the efficiency of alveolar decortication and low level laser therapy on orthodontic tooth movement and alveolar metabolism in rats.Journal of dental sciences · 2019Article
- The influence of leukocyte-platelet-rich plasma on accelerated orthodontic tooth movement in rabbits.Korean journal of orthodontics · 2019Article
- Comparison of tooth movement and biological response in corticotomy and micro-osteoperforation in rabbits.Korean journal of orthodontics · 2019Article
- Periodontal Accelerated Osteogenic Orthodontics Technique for Rapid Orthodontic Tooth Movement: A Systematic Review.Journal of pharmacy & bioallied sciences · 2019Review
- Facial asymmetry correction: From conventional orthognathic treatment to surgery-first approach.Journal of dental research, dental clinics, dental prospects · 2019Review
- The effects of alveolar decortications on orthodontic tooth movement and bone remodelling in rats.European journal of orthodontics · 2018Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn the current study, we aimed to investigate the effects of alveolar decortication on local bone remodeling, and to explore the possible mechanism by which decortication facilitates tooth movement. MATERIALS AND
methodsForty rabbits were included in the experiment. The left mandible was subjected to decortication-facilitated orthodontics, and the right mandible underwent traditional orthodontics as a control. The animals were sacrificed on the days 1, 3, 5, 7 and 14, after undergoing orthodontic procedures. Tooth movement was measured by Micro-CT, and the local periodontal tissues were investigated using H&E, Masson's trichrome and tartrate-resistant acid phosphatase (TRAP) staining. The mRNA levels of genes related to bone remodeling in the alveolar bone were analyzed using real-time PCR.
resultOn days 3, 5, 7 and 14, tooth movement was statistically accelerated by decortication (P<0.05) and was accompanied by increased hyperemia. Despite the lack of new bone formation in both groups, more osteoclasts were noted in the decorticated group, with two peak counts (P<0.05). The first peak count was consistent with the maximum values of ctsk and TRAP expression, and the second peak counts accompanied the maximum nfatc1 and jdp2 expression. The increased fra2 expression and the ratio of rankl/opg also accompanied the second peak counts.
conclusionsFollowing alveolar decortication, osteoclastogenesis was initially induced to a greater degree than the new bone formation which was thought to have caused a regional acceleratory phenomenon (RAP). The amount of steoclastogenesis in the decorticated alveolar bone was found to have two peaks, perhaps due to attenuated local resistance. The first peak count in osteoclasts may have been due to previously existing osteoclast precursors, whereas the second may represent the differentiation of peripheral blood mononuclear cells which came from circulation as the result of hyperemia.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.