ArticleJournal of the American Chemical Society2016
Diverted Total Synthesis of Promysalin Analogs Demonstrates That an Iron-Binding Motif Is Responsible for Its Narrow-Spectrum Antibacterial Activity.
Article in Journal of the American Chemical Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Target-Guided Design and Synthesis of Aryl-Functionalized Promysalin Analogs.Chembiochem : a European journal of chemical biology · 2025Article
- Investigating the Role of Metabolism for Antibiotic Combination Therapies inACS infectious diseases · 2023Article
- Bromotyrosine-Derived Metabolites from a Marine Sponge InhibitInternational journal of molecular sciences · 2023Article
- Structure-Based Design of Promysalin Analogues to Overcome Mechanisms of Bacterial Resistance.ACS omega · 2023Article
- Rhoda-Electrocatalyzed Bimetallic C-H Oxygenation by Weak O-Coordination.Angewandte Chemie (International ed. in English) · 2021Article
- Pyochelin Biosynthetic Metabolites Bind Iron and Promote Growth inACS infectious diseases · 2021Article
- Gatorbulin-1, a distinct cyclodepsipeptide chemotype, targets a seventh tubulin pharmacological site.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Structural Insights into JAK2 Inhibition by Ruxolitinib, Fedratinib, and Derivatives Thereof.Journal of medicinal chemistry · 2021Article
- Natural products as inspiration for the development of bacterial antibiofilm agents.Natural product reports · 2020Review
- Target-Based Design of Promysalin Analogues Identifies a New Putative Binding Cleft in Succinate Dehydrogenase.ACS infectious diseases · 2020Article
- Recent Progress in Natural-Product-Inspired Programs Aimed To Address Antibiotic Resistance and Tolerance.Journal of medicinal chemistry · 2019Review
- From General to Specific: Can Pseudomonas Primary Metabolism Be Exploited for Narrow-Spectrum Antibiotics?Chembiochem : a European journal of chemical biology · 2019Article
- Transcriptomic Profiling Suggests That Promysalin Alters the Metabolic Flux, Motility, and Iron Regulation in Pseudomonas putida KT2440.ACS infectious diseases · 2018Article
- General, Mild, and Selective Method for Desaturation of Aliphatic Amines.Journal of the American Chemical Society · 2018Article
- Diverted Total Synthesis of the Baulamycins and Analogues Reveals an Alternate Mechanism of Action.Organic letters · 2018Article
- Scalable Access to Arylomycins via C-H Functionalization Logic.Journal of the American Chemical Society · 2018Article
- Promysalin Elicits Species-Selective Inhibition of Pseudomonas aeruginosa by Targeting Succinate Dehydrogenase.Journal of the American Chemical Society · 2018Article
- Natural Products as Platforms To Overcome Antibiotic Resistance.Chemical reviews · 2017Review
- Promysalin is a salicylate-containing antimicrobial with a cell-membrane-disrupting mechanism of action on Gram-positive bacteria.Scientific reports · 2017Article
- Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms.Journal of the American Chemical Society · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Promysalin is a species-specific Pseudomonad metabolite with unique bioactivity. To better understand the mode of action of this natural product, we synthesized 16 analogs utilizing diverted total synthesis (DTS). Our analog studies revealed that the bioactivity of promysalin is sensitive to changes within its hydrogen bond network whereby alteration has drastic biological consequences. The DTS library not only yielded three analogs that retained potency but also provided insights that resulted in the identification of a previously unknown ability of promysalin to bind iron. These findings coupled with previous observations hint at a complex multifaceted role of the natural product within the rhizosphere.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.