ArticleAnnals of the American Thoracic Society2016
Blood Eosinophils and World Trade Center Exposure Predict Surgery in Chronic Rhinosinusitis. A 13.5-Year Longitudinal Study.
Article in Annals of the American Thoracic Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 19 citations in OpenAlex.
- Impact of World Trade Center dust exposure on upper-aero digestive tract disorders and sinonasal surgery: findings from patients seen in the Department of Otolaryngology - Head and Neck Surgery at Mount Sinai Hospital.Occupational and environmental medicine · 2026Article
- The Association between Dietary Habits and Rapid Postoperative Recovery of Rotator Cuff Repair.Nutrients · 2023Article
- World Trade Center dust induces nasal and neurological tissue injury while propagating reduced olfaction capabilities and increased anxiety behaviors.Inhalation toxicology · 2022Article
- Dynamic Metabolic Risk Profiling of World Trade Center Lung Disease: A Longitudinal Cohort Study.American journal of respiratory and critical care medicine · 2021Article
- Serum Th-2 cytokines and FEVAmerican journal of industrial medicine · 2021Article
- PEDF, a pleiotropic WTC-LI biomarker: Machine learning biomarker identification and validation.PLoS computational biology · 2021Article
- Long-term Cardiovascular Disease Risk Among Firefighters After the World Trade Center Disaster.JAMA network open · 2019Article
- Blood Leukocyte Concentrations, FEVAnnals of the American Thoracic Society · 2018Article
- The Effect of World Trade Center Exposure on the Timing of Diagnoses of Obstructive Airway Disease, Chronic Rhinosinusitis, and Gastroesophageal Reflux Disease.Frontiers in public health · 2017Article
- Biomarkers of patient intrinsic risk for upper and lower airway injury after exposure to the World Trade Center atrocity.American journal of industrial medicine · 2016Review
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Authors and funding
18 authors at 6 institutions in 2 countries.
Funding
Abstract
rationaleThe World Trade Center (WTC) collapse generated caustic airborne particulates that caused chronic rhinosinusitis in exposed Fire Department of New York firefighters. Surgery was performed when symptoms remained uncontrolled despite medical management.
objectivesTo identify predictors of surgical intervention for chronic rhinosinusitis in firefighters exposed to airborne irritants at the WTC collapse site.
methodsWe assessed in 8,227 firefighters with WTC exposure between September 11, 2001 (9/11), and September 25, 2001, including WTC-site arrival time, months of rescue and recovery work, and eosinophil concentration measured between 9/11 and March 10, 2003. We assessed the association of serum cytokines and immunoglobulins with eosinophil concentration and surgery for rhinosinusitis in 112 surgical cases and 376 control subjects with serum available from the first 6 months after exposure to the WTC collapse site. MEASUREMENTS AND MAIN
resultsBetween 9/11 and March 10, 2015, the surgery rate was 0.47 cases per 100 person-years. In the first 18 months post-9/11, surgical patients had higher mean blood eosinophil levels than study cohort patients (219 ± 155 vs. 191 ± 134; P < 0.0001). Increased surgery risk was associated with increasing blood eosinophil counts (hazard ratio [HR], 1.12 per 100 cells/μl; 95% confidence interval [CI], 1.07-1.17; P < 0.001); arriving at the WTC site on 9/11 or September 12, 2001 (HR, 1.43; 95% CI, 1.04-1.99; P = 0.03); and working 6 months or longer at the WTC site (HR, 1.48; 95% CI, 1.14-1.93; P < 0.01). Median blood eosinophil levels for surgical patients were above levels for the cohort in all 18-month intervals March 11, 2000, through March 10, 2015, using 51,163 measurements representing 97,733 person-years of observation. Increasing age, increasing IL-17A, and low IgA in serum from 2001 to 2002 predicted blood eosinophil concentration in surgical patients but not in control subjects (R(2) = 0.26, P < 0.0001; vs. R(2) = 0.008, P = 0.56).
conclusionsIncreasing blood eosinophil concentration predicts surgical intervention for chronic rhinosinusitis, particularly in those with intense acute and prolonged exposure to airborne irritants. WTC-exposed Fire Department of New York firefighters who underwent irritant-associated sinus surgery are immunologically different from the cohort. Surgical patients have a higher blood eosinophil levels that is associated with mediators of mucosal immunity.
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