Evidence map›Paper›PMID 27096188›Full record

ArticleLab animal2016

Recent refinements to cranial implants for rhesus macaques (Macaca mulatta).

Jessica M Johnston, Yale E Cohen, Harry Shirley, Joji Tsunada, Sharath Bennur, Kate Christison-Lagay, Christin L Veeder

Abstract read
In one paragraph

Article in Lab animal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Distinct Cortical Populations Drive Multisensory Modulation of Segregated Auditory Sources.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Association of Primate Veterinarians Cranial Implant Care for Nonhuman Primates in Biomedical Research.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021
    Article
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  11. Review
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Jessica M JohnstonDepartment of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA.
Yale E CohenDepartments of Otorhinolaryngology-Head and Neck Surgery, Neuroscience, and Bioengineering, University of Pennsylvania, Philadelphia, PA.
Harry ShirleyDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Joji TsunadaDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Sharath BennurDepartment of Otorhinolaryngology-Head and Neck Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Kate Christison-LagayNeuroscience Graduate Group, University of Pennsylvania, Philadelphia, PA.
Christin L VeederUniversity Laboratory Animal Resources, University of Pennsylvania, Philadelphia, PA.
University of Pennsylvania · US

Funding

Representations of sound processing in the auditory cortexR01DC009224 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI COHEN, YALE E · 2008 to 2018
$3.1M
Multi-scale study of auditory scene analysis in the ventral auditory pathwayR01DC013961 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI COHEN, YALE E, FISHMAN, YONATAN · 2015 to 2019
$2.3M
Auditory response properties of the prefrontal cortexR01DC007172 · NIDCD · UNIVERSITY OF PENNSYLVANIA · PI COHEN, YALE E · 2005 to 2009
$1.1M
NIDCD NIH HHS R01 DC007172NIDCD NIH HHS R01 DC009224NIDCD NIH HHS R01 DC013961
6 · The paper itself

Abstract

The advent of cranial implants revolutionized primate neurophysiological research because they allow researchers to stably record neural activity from monkeys during active behavior. Cranial implants have improved over the years since their introduction, but chronic implants still increase the risk for medical complications including bacterial contamination and resultant infection, chronic inflammation, bone and tissue loss and complications related to the use of dental acrylic. These complications can lead to implant failure and early termination of study protocols. In an effort to reduce complications, we describe several refinements that have helped us improve cranial implants and the wellbeing of implanted primates.

Indexed as

Acrylic ResinsAnimalsCraniotomyDental CementsImplants, ExperimentalMacaca mulattaMagnetic Resonance ImagingMonkey DiseasesNeurophysiologyPostoperative ComplicationsSkullSurgical Wound InfectionWound HealingAcrylic ResinsDental Cements

Identifiers

PMID27096188
PMCPMC5428389
OpenAlexW2340787443

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.