ArticleBrain and behavior2016
Homocysteinemia and early outcome of acute ischemic stroke in elderly patients.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- The Prognostic Value of Homocysteine in Acute Ischemic Stroke Patients: A Systematic Review and Meta-Analysis.Frontiers in systems neuroscience · 2020Pooled it
- Uncovering Hyperhomocysteinemia: Global Risk Patterns and Molecular Disruption in Brain and Vascular Health.Journal of neurochemistry · 2025Review
- Role and Relationship Between Homocysteine and HMolecular neurobiology · 2025Review
- Development and validation of a machine learning-based prognostic risk stratification model for acute ischemic stroke.Scientific reports · 2023Article
- Homocysteine Plasmatic Concentration in Brain-Injured Neurocritical Care Patients: Systematic Review of Clinical Evidence.Journal of clinical medicine · 2022Review
- Novel Predictors of Stroke-Associated Pneumonia: A Single Center Analysis.Frontiers in neurology · 2022Article
- Article
- The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice.International journal of molecular sciences · 2019Review
- Synergistic Effect of Atorvastatin and Folic Acid on Cardiac Function and Ventricular Remodeling in Chronic Heart Failure Patients with Hyperhomocysteinemia.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Association between homocysteine and conventional predisposing factors on risk of stroke in patients with hypertension.Scientific reports · 2018Article
- Elevated plasma homocysteine upon ischemic stroke is associated with increased long-term mortality in women.PloS one · 2017Article
- Homocysteinemia and early outcome of acute ischemic stroke in elderly patients.Brain and behavior · 2016Article
- Impacts of stress hyperglycemia ratio on functional outcomes of ischemic stroke patients treated with intravenous thrombolysis: a population-based study.Frontiers in neurologyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesPlasma total homocysteine (tHcy) is a risk factor for ischemic stroke (IS) but its relationship with IS outcome is uncertain. Moreover, previous studies underrepresented older IS patients, although risk of both hyperhomocysteinemia and IS increases with age. We investigated whether, in elderly patients with acute IS, tHcy measured on admission to the Stroke Unit (SU) is an independent predictor of SU discharge outcomes. MATERIALS AND
methodsData are for 644 consecutive patients aged 80.3 ± 8.7 years, admitted to an Italian SU with diagnosis of acute IS. Plasma tHcy was measured on SU admission. Investigated outcomes included mortality during SU stay and poor functional status (modified Rankin Scale score ≥3) at SU discharge for survivors. The association of plasma tHcy with the study outcomes was assessed using Odds Ratios (OR) and their corresponding 95% confidence intervals (95%CI) from logistic regression models adjusted for demographics, pre-stroke features, IS severity, and laboratory data on SU admission (serum C-reactive protein, serum albumin, and renal function).
resultsMedian plasma tHcy was 16.7 μmol/L (interquartile range, 13.0-23.3 μmol/L). Outcome incidence was 5.3% for mortality and 49.7% for poor functional status. Plasma tHcy was unrelated to mortality in both univariate and multivariable-adjusted analyses. Conversely, plasma tHcy was associated with poor functional status of survivors in univariate analyses (P = 0.014). Multivariable-adjusted analyses showed that, compared to normal homocysteinemia (tHcy <16 μmol/L), risk of being discharged with poor functional status significantly increased for moderate (tHcy ≥30 mol/L) but not mild (16.0-29.9 μmol/L) hyperhomocysteinemia.
conclusionsIn elderly patients with acute IS, high admission plasma tHcy is unrelated to mortality during SU stay but is an independent predictor of poor functional status at SU discharge in survivors. The association, however, is limited to patients with moderate hyperhomocysteinemia.
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