ArticleZhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology2016
[Role of lipin-1 in the pathogenesis of alcoholic fatty liver disease].
Article in Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 5 citations in OpenAlex.
- The correlation between different metabolic scores and the risk of cardiometabolic comorbidities in hypertensive patients.Scientific reports · 2025Article
- Investigating the Effect of Galbanic Acid on Lipin-1 and Lipin-2 Genes in Fatty Liver Cells with Palmitate.Advanced biomedical research · 2024Article
- Pathogenic mechanisms and regulatory factors involved in alcoholic liver disease.Journal of translational medicine · 2023Review
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2 authors at 1 institution in 1 country.
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Abstract
Lipin-1 can promote the synthesis of triglyceride and fatty acid oxidation during lipid metabolism. Ethanol can up-regulate the expression of lipin-1 via the AMPK-SREBP-1-lipin-1 signaling pathway and increase lipin1β/αratio via the SITR1-SFRS10-LPIN1 signaling pathway. In the cytoplasm, lipin-1βfunctions as a Mg2+-dependent phosphatidic acid phosphohydrolase to accelerate the synthesis of triglyceride. In the nucleus, lipin-1αacts as a transcriptional coactivator and reduces mitochondrial fatty acid oxidation by inhibiting the activities of PPARαand PGC-1α, and therefore promotes lipid deposition in hepatocytes and causes hepatic steatosis.
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Registered trials
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