ArticleCardiovascular diabetology2016
Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome.
Article in Cardiovascular diabetology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- The association between diabetes and dermal microvascular dysfunction non-invasively assessed by laser Doppler with local thermal hyperemia: a systematic review with meta-analysis.Cardiovascular diabetology · 2017Pooled it
- Individual cell motion in healthy human skin microvasculature by reflectance confocal video microscopy.Microcirculation (New York, N.Y. : 1994) · 2020Trial
- Impaired microcirculation in the skin and subclinical atherosclerosis in individuals with dysglycaemia in a large population-based cohort.Cardiovascular diabetology · 2025Article
- The association between triglyceride-glucose index, atherogenic index of plasma, systemic immune-inflammation index, and mortality in patients with acute coronary syndrome: the direct effects of glucose-lipid metabolism and U-shaped immune modulation in mortality risk.Frontiers in cardiovascular medicine · 2025Article
- Luteinizing hormone is independently associated with high-sensitive cardiac troponin T elevation in postmenopausal T2DM patients: A cross-sectional study.Journal of diabetes · 2024Article
- Mini Review: the non-neuronal cardiac cholinergic system in type-2 diabetes mellitus.Frontiers in cardiovascular medicine · 2024Review
- Assessment of Microcirculation in the Type 2 Diabetic and Impaired Glucose Tolerance Feet of Elderly Men by CEUS.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Relationship of Sarcopenia with Microcirculation Measured by Skin Perfusion Pressure in Patients with Type 2 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2020Article
- From Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA) to Chronic Coronary Syndrome: Clinical Diagnostic Use of Laser Doppler Flowmetry in Coronary Microvascular Dysfunction.The American journal of case reports · 2020Article
- Influence of 8-Week Aerobic Training on the Skin Microcirculation in Patients with Ischaemic Heart Disease.Journal of aging research · 2020Article
- The interrelation of endothelial function and microvascular reactivity in different vascular beds, and risk assessment in hypertension: results from the Doxazosin-ramipril study.Heart and vessels · 2019Article
- Diabetes, cardiovascular disease and the microcirculation.Cardiovascular diabetology · 2018Review
- The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control.Cardiovascular diabetology · 2017Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicrovascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS).
methodsMicrovascular function was evaluated in 83 patients by laser Doppler fluxmetry (LDF) [PU; perfusion unit, median (interquartile range)] measuring resting LDF and peak LDF following a six min heating of the skin to 44 °C at the foot, respectively. All patients with ACS and without previously known diabetes underwent oral glucose tolerance test. Thirty-nine patients with type 2 diabetes mellitus free from coronary artery disease served as controls.
resultsPeak LDF was significantly (P = 0.03) lower in patients with ACS and diabetes (n = 22; 72 (52)) and diabetes without coronary artery disease (n = 39; 69 (51)) as compared to patients with ACS without diabetes (n = 46; 97 (60)), and patients without ACS (n = 15; 140 (121)), respectively. Patients with ACS (n = 68) had significantly (P = 0.04) lower peak LDF (92 (49)) as compared to patients without ACS (n = 15) (140 (121)).
conclusionMicrovascular reactivity is severely impaired in patients with diabetes and ACS. Diabetes has a major influence on microvascular function in patients with coronary artery disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.