Evidence map›Paper›PMID 27095425›Full record

Observational studyJournal of clinical pharmacology2016

Role of Tiotropium in Reducing Exacerbations of Chronic Obstructive Pulmonary Disease When Combined With Long-Acting β

Eliana Ferroni, Valeria Belleudi, Silvia Cascini, Mirko Di Martino, Ursula Kirchmayer, Riccardo Pistelli, Elisabetta Patorno, Giulio Formoso, Danilo Fusco, Carlo A Perucci and 3 more

Open access · hybridAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of clinical pharmacology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Lung and kidney: a dangerous liaison? A population-based cohort study in COPD patients in Italy.International journal of chronic obstructive pulmonary disease · 2017
    Article
  4. Review
  5. Article
  6. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Eliana FerroniDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Valeria BelleudiDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Silvia CasciniDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Mirko Di MartinoDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Ursula KirchmayerDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Riccardo PistelliDepartment of Respiratory Physiology, Catholic University, Rome, Italy.
Elisabetta PatornoDivision of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women's Hospital, Boston, MA, USA.
Giulio FormosoEmilia-Romagna Regional Health and Social Care Agency, Bologna, Italy.
Danilo FuscoDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Carlo A PerucciNational Outcome Evaluation Program, National Agency for Regional Health Services, Rome, Italy.
Marina DavoliDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Nera AgabitiDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy. n.agabiti@deplazio.it.
OUTPUL Study GroupDepartment of Epidemiology, Lazio Regional Health Service, Rome, Italy.
Agenzia Regionale per la Protezione Ambientale del Piemonte · ITAgenzia Sanitaria e Sociale Regionale · ITBrigham and Women's Hospital · USUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Combined inhaled therapy in chronic obstructive pulmonary disease (COPD) is commonly used, but its benefits remain controversial. We assessed the effect of tiotropium in reducing COPD exacerbations when combined with long-acting β

Indexed as

Administration, InhalationAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsAgedAged, 80 and overBronchodilator AgentsCohort StudiesDrug Therapy, CombinationFemaleFollow-Up StudiesHumansItalyMaleMiddle AgedPulmonary Disease, Chronic ObstructiveTiotropium BromideAdrenal Cortex HormonesAdrenergic beta-2 Receptor AgonistsBronchodilator AgentsTiotropium Bromidechronic obstructive pulmonary diseasecomparative effectivenessexacerbationinhaled therapytiotropium

Identifiers

PMID27095425
PMCPMC5111769
OpenAlexW2339627152

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.