Evidence map›Paper›PMID 27095366›Full record

ReviewCellular and molecular neurobiology2016

The Science of Vascular Contributions to Cognitive Impairment and Dementia (VCID): A Framework for Advancing Research Priorities in the Cerebrovascular Biology of Cognitive Decline.

Roderick A Corriveau, Francesca Bosetti, Marian Emr, Jordan T Gladman, James I Koenig, Claudia S Moy, Katherine Pahigiannis, Salina P Waddy, Walter Koroshetz

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cellular and molecular neurobiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 2 pooled it
11.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 2 syntheses or guidelines pooled it, 232 citations in OpenAlex.

  1. Pooled it
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  6. Review
  7. Article
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  10. Cognitive reserve against vascular contributions to cognitive impairment and dementia: A scoping review.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  11. Article
  12. Review
  13. Article
  14. Vascular contribution to cognitive impairment and dementia (VCID): proceedings of 2025 workshop of the Jackson Laboratory.Mammalian genome : official journal of the International Mammalian Genome Society · 2026
    Article
  15. Article
  16. Observational
  17. Article
  18. Review
  19. Review
  20. Article

119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Roderick A CorriveauNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA. roderick.corriveau@nih.gov.
Francesca BosettiNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
Marian EmrNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
Jordan T GladmanNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
James I KoenigNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
Claudia S MoyNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
Katherine PahigiannisNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
Salina P WaddyNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
Walter KoroshetzNational Institute of Neurological Disorders and Stroke (NINDS), National Institutes of Health (NIH), 6001 Executive Blvd, Bethesda, MD, 20892-9525, USA.
National Institutes of Health · USNational Institute of Neurological Disorders and Stroke · US

Funding

Intramural NIH HHS Z99 NS999999
6 · The paper itself

Abstract

The World Health Organization reports that 47.5 million people are affected by dementia worldwide. With aging populations and 7.7 million new cases each year, the burden of illness due to dementia approaches crisis proportions. Despite significant advances in our understanding of the biology of Alzheimer's disease (AD), the leading dementia diagnosis, the actual causes of dementia in affected individuals are unknown except for rare fully penetrant genetic forms. Evidence from epidemiology and pathology studies indicates that damage to the vascular system is associated with an increased risk of many types of dementia. Both Alzheimer's pathology and cerebrovascular disease increase with age. How AD affects small blood vessel function and how vascular dysfunction contributes to the molecular pathology of Alzheimer's are areas of intense research. The science of vascular contributions to cognitive impairment and dementia (VCID) integrates diverse aspects of biology and incorporates the roles of multiple cell types that support the function of neural tissue. Because of the proven ability to prevent and treat cardiovascular disease and hypertension with population benefits for heart and stroke outcomes, it is proposed that understanding and targeting the biological mechanisms of VCID can have a similarly positive impact on public health.

Indexed as

ResearchAnimalsCognitive DysfunctionCost of IllnessDementia, VascularHumansModels, BiologicalAlzheimer’s diseaseCardiovascularCerebrovascularVascular cognitive impairment, VCIVascular contributions to cognitive impairment and dementia, VCIDVascular dementia

Identifiers

PMID27095366
PMCPMC4859348
OpenAlexW2340837185

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.