ArticleScientific reports2016
Voxel-based analysis of grey and white matter degeneration in cervical spondylotic myelopathy.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 66 citations in OpenAlex.
- Recovery of thalamic damage after decompression byBMC medical imaging · 2026Article
- Spinal cord diffusion tensor imaging predicts balance in degenerative cervical myelopathy.Frontiers in neuroscience · 2026Article
- Multimodal MRI links gray matter volume loss and temporal lobe susceptibility to CSF immunological profiles in Guillain-Barré syndrome.Frontiers in immunology · 2026Article
- Semiautomated Pipeline Effectively Assesses Severity and Monitor Disease Progression in Compressed Spinal Cord of Degenerative Cervical Myelopathy Patients.Neurosurgery practice · 2025Article
- Evaluation of magnetic resonance spectroscopy total sodium concentration measures, and associations with microstructure and physical impairment in cervical myelopathy.Scientific reports · 2025Article
- Test-retest repeatability of intravoxel incoherent motion (IVIM) measurements in the cervical cord.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Altered brain network centrality in patients with cervical spondylotic myelopathy: insights from resting-state fMRI.Frontiers in neurology · 2025Article
- Quantifying neurodegeneration of the cervical cord and brain in degenerative cervical myelopathy: A multicentre study using quantitative magnetic resonance imaging.European journal of neurology · 2024Article
- Neurodegeneration within the rostral spinal cord is associated with brain gray matter volume atrophy in the early stage of cervical spondylotic myelopathy.Spinal cord · 2024Article
- Metabolic changes of thalamus assessed byFrontiers in neurology · 2024Article
- ACID: A comprehensive toolbox for image processing and modeling of brain, spinal cord, and ex vivo diffusion MRI data.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Evidence-based commentary on the diagnosis, management, and further research of degenerative cervical spinal cord compression in the absence of clinical symptoms of myelopathy.Frontiers in neurology · 2024Review
- Investigation of perfusion impairment in degenerative cervical myelopathy beyond the site of cord compression.Scientific reports · 2023Article
- Utility of MRI in Quantifying Tissue Injury in Cervical Spondylotic Myelopathy.Journal of clinical medicine · 2023Review
- Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy.Frontiers in neuroscience · 2023Article
- Clinical and Research MRI Techniques for Assessing Spinal Cord Integrity in Degenerative Cervical Myelopathy-A Scoping Review.Biomedicines · 2022Article
- Optimized multi-echo gradient-echo magnetic resonance imaging for gray and white matter segmentation in the lumbosacral cord at 3 T.Scientific reports · 2022Article
- Quantitative MR Markers in Non-Myelopathic Spinal Cord Compression: A Narrative Review.Journal of clinical medicine · 2022Review
- Semi-automated detection of cervical spinal cord compression with the Spinal Cord Toolbox.Quantitative imaging in medicine and surgery · 2022Article
- Degenerative cervical myelopathy delays responses to lateral balance perturbations regardless of predictability.Journal of neurophysiology · 2022Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 3 countries.
Funding
Abstract
In this prospective study, we made an unbiased voxel-based analysis to investigate above-stenosis spinal degeneration and its relation to impairment in patients with cervical spondylotic myelopathy (CSM). Twenty patients and 18 controls were assessed with high-resolution MRI protocols above the level of stenosis. Cross-sectional areas of grey matter (GM), white matter (WM), and posterior columns (PC) were measured to determine atrophy. Diffusion indices assessed tract-specific integrity of PC and lateral corticospinal tracts (CST). Regression analysis was used to reveal relationships between MRI measures and clinical impairment. Patients showed mainly sensory impairment. Atrophy was prominent within the cervical WM (13.9%, p = 0.004), GM (7.2%, p = 0.043), and PC (16.1%, p = 0.005). Fractional anisotropy (FA) was reduced in the PC (-11.98%, p = 0.006) and lateral CST (-12.96%, p = 0.014). In addition, radial (+28.47%, p = 0.014), axial (+14.72%, p = 0.005), and mean (+16.50%, p = 0.001) diffusivities were increased in the PC. Light-touch score was associated with atrophy (R(2) = 0.3559, p = 0.020) and FA (z score 3.74, p = 0.003) in the PC, as was functional independence and FA in the lateral CST (z score 3.68, p = 0.020). This study demonstrates voxel-based degeneration far above the stenosis at a level not directly affected by the compression and provides unbiased readouts of tract-specific changes that relate to impairment.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.