ArticleJournal of neurovirology2016
Elevated stress is associated with prefrontal cortex dysfunction during a verbal memory task in women with HIV.
Article in Journal of neurovirology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Comorbidities in women living with HIV: A systematic review.HIV medicine · 2022Pooled it
- Associations Between Internalized HIV Stigma and Cognitive Function Among Older Women With HIV.The journals of gerontology. Series B, Psychological sciences and social sciences · 2025Article
- Cognitive Health in Persons With Human Immunodeficiency Virus: The Impact of Early Treatment, Comorbidities, and Aging.The Journal of infectious diseases · 2023Article
- Starting or Switching to an Integrase Inhibitor-Based Regimen Affects PTSD Symptoms in Women with HIV.AIDS and behavior · 2021Article
- Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort.Current topics in behavioral neurosciences · 2021Review
- Neurocognitive Complications of HIV Infection in Women: Insights from the WIHS Cohort.Current topics in behavioral neurosciences · 2021Review
- The relationship between potentially traumatic or stressful events, HIV infection and neurocognitive impairment (NCI): a systematic review of observational epidemiological studies.European journal of psychotraumatology · 2020Review
- Depression and Psychosocial Stress Are Associated With Subclinical Carotid Atherosclerosis Among Women Living With HIV.Journal of the American Heart Association · 2020Observational
- Associations of food insecurity and psychosocial measures with diet quality in adults aging with HIV.AIDS care · 2019Article
- Effects of trauma, economic hardship, and stress on neurocognition and everyday function in HIV.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2019Article
- Differences in Cognitive Function Between Women and Men With HIV.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Microglial activation is inversely associated with cognition in individuals living with HIV on effective antiretroviral therapy.AIDS (London, England) · 2018Article
- Use of Nonantiretroviral Medications That May Impact Neurocognition: Patterns and Predictors in a Large, Long-Term HIV Cohort Study.Journal of acquired immune deficiency syndromes (1999) · 2018Article
- Perceived and post-traumatic stress are associated with decreased learning, memory, and fluency in HIV-infected women.AIDS (London, England) · 2017Article
- Aging and Neurocognitive Functioning in HIV-Infected Women: a Review of the Literature Involving the Women's Interagency HIV Study.Current HIV/AIDS reports · 2016Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
HIV-infected women may be particularly vulnerable to verbal learning and memory deficits. One factor contributing to these deficits is high perceived stress, which is associated with prefrontal cortical (PFC) atrophy and memory outcomes sensitive to PFC function, including retrieval and semantic clustering. We examined the association between stress and PFC activation during a verbal memory task in 36 HIV-infected women from the Chicago Consortium of the Women's Interagency HIV Study (WIHS) to better understand the role of the PFC in this stress-related impairment. Participants completed standardized measures of verbal learning and memory and stress (perceived stress scale-10). We used functional magnetic resonance imaging to assess brain function while participants completed encoding and recognition phases of a verbal memory task. HIV-infected women with higher stress (scores in top tertile) performed worse on all verbal memory outcomes including strategic encoding (p < 0.05) compared to HIV-infected women with lower stress (scores in lower two tertiles). Patterns of brain activation during recognition (but not encoding) differed between women with higher vs. lower stress. During recognition, women with higher stress demonstrated greater deactivation in medial PFC and posterior cingulate cortex compared to women with lower stress (p < 0.05). Greater deactivation in medial PFC marginally related to less efficient strategic retrieval (p = 0.06). Similar results were found in analyses focusing on PTSD symptoms. Results suggest that stress might alter the function of the medial PFC in HIV-infected women resulting in less efficient strategic retrieval and deficits in verbal memory.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.