Evidence map›Paper›PMID 27094868›Full record

ReviewAdvanced healthcare materials2016

Biodegradable Metals for Cardiovascular Stents: from Clinical Concerns to Recent Zn-Alloys.

Patrick K Bowen, Emily R Shearier, Shan Zhao, Roger J Guillory, Feng Zhao, Jeremy Goldman, Jaroslaw W Drelich

Open access · greenAbstract readReview
In one paragraph

Review in Advanced healthcare materials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed, 1 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed, 1 synthesis or guideline pooled it, 511 citations in OpenAlex.

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61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Patrick K BowenDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, MI, 49931.
Emily R ShearierDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931.
Shan ZhaoDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, MI, 49931.
Roger J GuilloryDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931.
Feng ZhaoDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931.
Jeremy GoldmanDepartment of Biomedical Engineering, Michigan Technological University, Houghton, MI, 49931.
Jaroslaw W DrelichDepartment of Materials Science and Engineering, Michigan Technological University, Houghton, MI, 49931.
Michigan Technological University · US

Funding

Biodegradation mechanism and rate, biocompatibility, and toxicity for novel Zn-Mg stent materialsR15HL129199 · NHLBI · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI GOLDMAN, JEREMY · 2015 to 2015
$442k
Improved Biocompatibility and Biodegradation of Zn-based Stent Materials through Surface Nano-EngineeringR21EB019118 · NIBIB · MICHIGAN TECHNOLOGICAL UNIVERSITY · PI DRELICH, JAROSLAW W · 2015 to 2016
$386k
NHLBI NIH HHS R15 HL129199NIBIB NIH HHS R21 EB019118
6 · The paper itself

Abstract

Metallic stents are used to promote revascularization and maintain patency of plaqued or damaged arteries following balloon angioplasty. To mitigate the long-term side effects associated with corrosion-resistant stents (i.e., chronic inflammation and late stage thrombosis), a new generation of so-called "bioabsorbable" stents is currently being developed. The bioabsorbable coronary stents will corrode and be absorbed by the artery after completing their task as vascular scaffolding. Research spanning the last two decades has focused on biodegradable polymeric, iron-based, and magnesium-based stent materials. The inherent mechanical and surface properties of metals make them more attractive stent material candidates than their polymeric counterparts. A third class of metallic bioabsorbable materials that are based on zinc has been introduced in the last few years. This new zinc-based class of materials demonstrates the potential for an absorbable metallic stent with the mechanical and biodegradation characteristics required for optimal stent performance. This review compares bioabsorbable materials and summarizes progress towards bioabsorbable stents. It emphasizes the current understanding of physiological and biological benefits of zinc and its biocompatibility. Finally, the review provides an outlook on challenges in designing zinc-based stents of optimal mechanical properties and biodegradation rate.

Indexed as

Absorbable ImplantsAlloysAnimalsBiocompatible MaterialsCoronary Artery DiseaseHumansMetalsStentsZincAlloysBiocompatible MaterialsMetalsZincbiodegradable stentcardiovascular diseaseendovascular stentzinc

Identifiers

PMID27094868
PMCPMC4904226
OpenAlexW2341804378

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.