ArticleScientific reports2016
Isolation and molecular characterisation of Achromobacter phage phiAxp-3, an N4-like bacteriophage.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 42 citations in OpenAlex.
- An N4-likeJournal of bacteriology · 2026Article
- Characterization and genome analysis of the Klebsiella webervirus vB_KpnS_2146-302.Archives of virology · 2025Article
- An N4-likebioRxiv : the preprint server for biology · 2025Article
- A novel broad host range phage phiA85 displays a synergistic effect with antibiotics targeting carbapenem-resistantMicrobiology spectrum · 2025Article
- Characterization and genome analysis of Klebsiella phages with lytic activity against Klebsiella pneumoniae.Virus genes · 2025Article
- Phage therapy could be key to conquering persistent bacterial lung infections in children.npj antimicrobials and resistance · 2024Review
- Isolation and characterization of lytic bacteriophages from various sources in Addis Ababa against antimicrobial-resistant diarrheagenic Escherichia coli strains and evaluation of their therapeutic potential.BMC infectious diseases · 2024Article
- CompoundingViruses · 2023Article
- Characterization of a novel Jerseyvirus phage T102 and its inhibition effect on biofilms of multidrug-resistant Salmonella.Virus research · 2023Article
- In Vitro Activity, Stability and Molecular Characterization of Eight Potent Bacteriophages Infecting Carbapenem-ResistantViruses · 2022Article
- Bacteriophage Effectively Rescues Pneumonia Caused by Prevalent Multidrug-ResistantMicrobiology spectrum · 2022Article
- Isolation and characterization of a Vibrio owensii phage phi50-12.Scientific reports · 2022Article
- Article
- Isolation and Characterization of Novel Lytic Bacteriophage vB_RsoP_BMB50 infecting Ralstonia solanacearum.Current microbiology · 2022Article
- Isolation and Characterization of a NovelViruses · 2022Article
- Article
- A case of meningitis due toThe Pan African medical journal · 2021Article
- Characterization of Novel Lytic Bacteriophages ofViruses · 2020Article
- From Orphan Phage to a Proposed New Family-the Diversity of N4-Like Viruses.Antibiotics (Basel, Switzerland) · 2020Article
- Exploring the Remarkable Diversity of CulturableViruses · 2020Article
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Achromobacter xylosoxidans, an opportunistic pathogen, is responsible for various nosocomial and community-acquired infections. We isolated phiAxp-3, an N4-like bacteriophage that infects A. xylosoxidans, from hospital waste and studied its genomic and biological properties. Transmission electron microscopy revealed that, with a 67-nm diameter icosahedral head and a 20-nm non-contractile tail, phiAxp-3 has features characteristic of Podoviridae bacteriophages (order Caudovirales). With a burst size of 9000 plaque-forming units and a latent period of 80 min, phiAxp-3 had a host range limited to only four A. xylosoxidans strains of the 35 strains that were tested. The 72,825 bp phiAxp-3 DNA genome, with 416-bp terminal redundant ends, contains 80 predicted open reading frames, none of which are related to virulence or drug resistance. Genome sequence comparisons place phiAxp-3 more closely with JWAlpha and JWDelta Achromobacter phages than with other N4 viruses. Using proteomics, we identified 25 viral proteins from purified phiAxp-3 particles. Notably, investigation of the phage phiAxp-3 receptor on the surface of the host cell revealed that lipopolysaccharide serves as the receptor for the adsorption of phage phiAxp-3. Our findings advance current knowledge about A. xylosoxidans phages in an age where alternative therapies to combat antibiotic-resistant bacteria are urgently needed.
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