ArticleScientific reports2016
Diarrhoea in the critically ill is common, associated with poor outcome, and rarely due to Clostridium difficile.
Article in Scientific reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 3 of them syntheses that pooled it.
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Who cites it
34 citing papers in PubMed, 3 syntheses or guidelines pooled it, 80 citations in OpenAlex.
- The efficacy of fiber-supplemented enteral nutrition in critically ill patients: a systematic review and meta-analysis of randomized controlled trials with trial sequential analysis.Critical care (London, England) · 2024Pooled it
- The safety and efficacy of probiotic supplementation for critically ill adult patients: a systematic review and meta-analysis.Nutrition reviews · 2023Pooled it
- The effect of fiber supplementation on the prevention of diarrhea in hospitalized patients receiving enteral nutrition: A meta-analysis of randomized controlled trials with the GRADE assessment.Frontiers in nutrition · 2022Pooled it
- A pilot study of alternative substrates in the critically Ill subject using a ketogenic feed.Nature communications · 2023Trial
- Translation and psychometric evaluation of the Chinese version of the King's Stool Chart in patients receiving enteral nutrition.BMJ open · 2026Article
- Gastrointestinal Tolerance toIndian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- An evaluation based on explainable machine learning: analysis of risk factors for enteral nutrition-related diarrhea in patients with severe stroke.Frontiers in nutrition · 2026Article
- Adjunctive use ofTranslational gastroenterology and hepatology · 2026Article
- Development and validation of an interpretable machine learning model for predicting enteral nutrition-associated diarrhea in ICU patients: a multicenter study.Frontiers in nutrition · 2026Article
- Antibiotic Use, Healthcare-Associated Infections, and Antimicrobial Resistance in Intensive Care Unit of a Serbian Tertiary University Hospital, 2018-2024: An Ecological Analysis.Antibiotics (Basel, Switzerland) · 2025Article
- Classifying diarrhea in critically ill patients through various criteria: a cohort study.Journal of intensive care · 2025Article
- The Japanese Critical Care Nutrition Guideline 2024.Journal of intensive care · 2025Review
- The association between defecation frequency and mortality in critically ill patients with suspected sepsis in Israel.Acute and critical care · 2025Article
- Guidelines for Antibiotics Prescription in Critically Ill Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024Article
- Clinical decision support for gastrointestinal panel testing.Antimicrobial stewardship & healthcare epidemiology : ASHE · 2024Article
- Gut Microbiota and Critically Ill Patients: Immunity and Its Modulation via Probiotics and Immunonutrition.Nutrients · 2023Review
- Dose-response relationship between diarrhea quantity and mortality in critical care patients: A retrospective cohort study.PloS one · 2023Article
- [Prevalence of diarrhea in adult patients in intensive care and its relationship with ready-to-use enteral formulas]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2022Article
- Diarrhea during critical illness: a multicenter cohort study.Intensive care medicine · 2022Article
- The influence of hospitalization and HIV severity on gastrointestinal PCR panel evaluation of HIV-related acute diarrhea in New York City: a retrospective, cross-sectional study.Therapeutic advances in gastroenterology · 2022Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Diarrhoea is common in Intensive Care Unit (ICU) patients, with a reported prevalence of 15-38%. Many factors may cause diarrhoea, including Clostridium difficile, drugs (e.g. laxatives, antibiotics) and enteral feeds. Diarrhoea impacts on patient dignity, increases nursing workload and healthcare costs, and exacerbates morbidity through dermal injury, impaired enteral uptake and subsequent fluid imbalance. We analysed a cohort of 9331 consecutive patients admitted to a mixed general intensive care unit to establish the prevalence of diarrhoea in intensive care unit patients, and its relationship with infective aetiology and clinical outcomes. We provide evidence that diarrhoea is common (12.9% (1207/9331) prevalence) in critically ill patients, independently associated with increased intensive care unit length of stay (mean (standard error) 14.8 (0.26) vs 3.2 (0.09) days, p < 0.001) and mortality (22.0% (265/1207) vs 8.7% (705/8124), p < 0.001; adjusted hazard ratio 1.99 (95% CI 1.70-2.32), p < 0.001) compared to patients without diarrhoea even after adjusting for potential confounding factors, and infrequently caused by infective aetiology (112/1207 (9.2%)) such as Clostridium difficile (97/1048 (9.3%) tested) or virological causes (9/172 (5.7%) tested). Our findings suggest non-infective causes of diarrhoea in ICU predominate and pathophysiology of diarrhoea in critically ill patients warrants further investigation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.