ArticleWorld journal of surgical oncology2016
Sentinel node biopsy during thoracolaparoscopic esophagectomy for advanced esophageal cancer.
Article in World journal of surgical oncology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 13 citations in OpenAlex.
- Article
- The Role of Four New Biochemical Markers in the Diagnosis and Prognosis of Ovarian Carcinoma.Reproductive sciences (Thousand Oaks, Calif.) · 2026Article
- [Evidence for the extent and oncological benefit of lymphadenectomy for esophageal cancer].Chirurgie (Heidelberg, Germany) · 2025Article
- Article
- Clinical Effect and Postoperative Pain of Laparo-Thoracoscopic Esophagectomy in Patients with Esophageal Cancer.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Robotic-assisted minimally invasive esophagectomy: past, present and future.Journal of thoracic disease · 2020Review
- Sentinel node navigation surgery in esophageal cancer.Annals of gastroenterological surgery · 2019Review
- The extent of lymphadenectomy in esophageal resection for cancer should be standardized.Journal of thoracic disease · 2017Review
- Identification of the Lymphatic Drainage Pattern of Esophageal Cancer with Near-Infrared Fluorescent Imaging.Journal of laparoendoscopic & advanced surgical techniques. Part A · 2017Article
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8 authors at 4 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOmitting extensive lymph node dissection could reduce esophagectomy morbidity in patients without lymph node metastases. Sentinel node biopsy may identify abdominal or thoracic lymph node metastases, thereby differentiating treatment. Feasibility of this approach was investigated in Western European esophageal cancer patients with advanced disease, without lymph node metastases at diagnostic work-up.
methodsThe sentinel node biopsy was performed in eight esophageal cancer patients with cT1-3N0 disease. One day pre-operatively, Tc-99m-labeled nanocolloid was endoscopically injected around the tumor. Lymphoscintigraphy was performed 1 and 3 h after injection. All patients underwent robotic thoracolaparoscopic esophagectomy with two-field lymph node dissection. Intraoperatively, sentinel nodes were detected by gamma probe. The resection specimen was analyzed for remaining activity by scintigraphy and gamma probe.
resultsVisualization rates of lymphoscintigraphy 1 and 3 h after tracer injection were 88 and 100%, respectively. Intraoperative identification rate was 38%. Postoperative identification was possible in all patients using the gamma probe to analyze the resection specimen. In 5/8 patients, lymph node metastases were found at histopathology, none of which was detected by the sentinel node biopsy. No adverse events related to the sentinel node biopsy were observed.
conclusionsIn our advanced esophageal cancer patients who underwent thoracolaparoscopic esophagectomy, the sentinel node biopsy did not predict lymph node status. Probably the real sentinel node could not be identified due to localization adjacent to the primary tumor or bypassing due to metastatic tumor involvement. Therefore, we consider the sentinel node biopsy not feasible in advanced esophageal cancer.
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