ArticleClinical and experimental medicine2017
Effects of lifelong exercise training on mammary tumorigenesis induced by MNU in female Sprague-Dawley rats.
Article in Clinical and experimental medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Effects of Ladder-Climbing Exercise on Mammary Cancer: Data from a Chemically Induced Rat Model.Veterinary sciences · 2025Article
- Article
- Successful hormonal and chemical induction of prostate cancer in a rat model: practical guidelines.Veterinary research forum : an international quarterly journal · 2024Review
- Realistic aspects behind the application of the rat model of chemically-induced mammary cancer: Practical guidelines to obtain the best results.Veterinary world · 2023Review
- Mammary Glands of Women, Female Dogs and Female Rats: Similarities and Differences to Be Considered in Breast Cancer Research.Veterinary sciences · 2023Review
- Effect of Exercise on Breast Cancer: A Systematic Review and Meta-analysis of Animal Experiments.Frontiers in molecular biosciences · 2022Review
- Intraductal administration of N-methyl-N-nitrosourea as a novel rodent mammary tumor model.Annals of translational medicine · 2021Article
- Synergistic Effects of Exercise Training and Vitamin D Supplementation on Mitochondrial Function of Cardiac Tissue, Antioxidant Capacity, and Tumor Growth in Breast Cancer in Bearing-4T1 Mice.Frontiers in physiology · 2021Article
- Impact of physical activity and energy restriction on immune regulation of cancer.Translational cancer research · 2020Review
- Dietary phytochemicals as the potential protectors against carcinogenesis and their role in cancer chemoprevention.Clinical and experimental medicine · 2020Review
- Physical Activity and Breast Cancer Prevention: Possible Role of Immune Mediators.Frontiers in nutrition · 2020Review
- Studying humane endpoints in a rat model of mammary carcinogenesis.Iranian journal of basic medical sciences · 2019Article
- Anti-tumoral effects of exercise on hepatocellular carcinoma growth.Hepatology communications · 2018Article
- Effects of exercise training on breast cancer metastasis in a rat model.International journal of experimental pathology · 2017Article
- The Impact of Exercise Training on Breast Cancer.In vivo (Athens, Greece)Article
- The impact of exercise training on adipose tissue remodelling in cancer cachexia.Porto biomedical journalReview
- Effect of Physical Training on the Levels of Sex Hormones and the Expression of Their Receptors in Rats With Induced Mammary Cancer in Secondary Prevention Model - Preliminary Study.In vivo (Athens, Greece)Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Breast cancer is the most common malignancy in women worldwide. Several studies have suggested that exercise training may decrease the risk of breast cancer development. This study aimed to evaluate the effects of long-term exercise training on mammary tumorigenesis in an animal model of mammary cancer. Fifty female Sprague-Dawley rats were randomly divided into four groups: MNU sedentary, MNU exercised, control sedentary and control exercised. Animals from MNU groups received an intraperitoneal administration of N-methyl-N-nitrosourea (MNU). Animals were exercised on a treadmill during 35 weeks. When animals were killed, blood samples were collected to determine the hematocrit and to perform the biochemical analysis. Mammary tumors were collected and histologically evaluated; the expression of ERs α and β was evaluated in tumor sections by immunohistochemistry. All survived animals from both MNU groups developed mammary tumors. The number of mammary tumors (p > 0.05) and lesions (p = 0.056) was lower in MNU exercised than in MNU sedentary animals. MNU exercised animals showed lower number of malignant lesions than MNU sedentary animals (p = 0.020). C-reactive protein serum concentration was lower in exercised animals; however, the levels of 17-β estradiol were higher in exercised animals. Tumors from exercised animals exhibited higher expression of ER α than tumors from sedentary animals (p < 0.05). This study analyzes the impact of the longest exercise training protocol on mammary tumorigenesis ever performed. We concluded that the lifelong endurance training has beneficial effects on mammary tumorigenesis in female rats (reduced the inflammation, the number of mammary tumors and lesions, and histological grade of malignancy). Additionally, the mammary tumors from MNU exercised group exhibited higher immunoexpression of ER α that is an indicator of well-differentiated tumors and better response to hormone therapy.
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