Evidence map›Paper›PMID 27094256›Full record

ArticleBMC infectious diseases2016

Dirofilaria repens: emergence of autochthonous human infections in the Czech Republic (case reports).

Jana Matějů, Marta Chanová, David Modrý, Barbora Mitková, Kristýna Hrazdilová, Víta Žampachová, Libuše Kolářová

Open access · goldAbstract read
In one paragraph

Article in BMC infectious diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. A Rare Case Report of a HumanMicroorganisms · 2025
    Article
  5. Subcutaneous dirofilariasis.Oxford medical case reports · 2025
    Article
  6. Article
  7. A Rare Case of Dirofilariasis in the Genian Region.Diagnostics (Basel, Switzerland) · 2024
    Article
  8. HumanIranian journal of public health · 2023
    Article
  9. One health (Amsterdam, Netherlands) · 2021
    Review
  10. Pathogens (Basel, Switzerland) · 2021
    Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Subcutaneous Dirofilariasis in Female Pubic Region - Case Report.Open access Macedonian journal of medical sciences · 2019
    Article
  18. Review
  19. Xenomonitoring of Mosquitoes (Diptera: Culicidae) for the Presence of Filarioid Helminths in Eastern Austria.The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2018
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Jana MatějůInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
Marta ChanováInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic.
David ModrýDepartment of Pathology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Barbora MitkováDepartment of Pathology and Parasitology, Faculty of Veterinary Medicine, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Kristýna HrazdilováCentral European Institute for Technology, University of Veterinary and Pharmaceutical Sciences, Brno, Czech Republic.
Víta ŽampachováFirst Department of Pathological Anatomy, Faculty of Medicine, Masaryk University - St. Anne's University Hospital Brno, Brno, Czech Republic.
Libuše KolářováInstitute of Immunology and Microbiology, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic. Libuse.Kolarova@lf1.cuni.cz.
Charles University · CZUniversity of Veterinary Sciences Brno · CZMasaryk University · CZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHuman dirofilariasis is a zoonotic infection that continues to spread to previously unaffected areas of Europe. In the South Moravian Region of the Czech Republic (CR), imported as well as autochthonous canine infections were recorded in the last decade, and parasite DNA was detected in mosquitoes of Aedes vexans. In the present paper, human Dirofilaria infections are reported from the country for the first time. CASE PRESENTATION: The samples from five patients with suspected tissue helminthiases were investigated. In particular cases, nematodes were isolated from various tissues including skin of lower leg, soft tissues of finger, subcutaneous tissue of hypogastrium, lymph node and peritoneum. The diagnosis was based on light microscopic morphology and/or DNA analysis of the worms. In addition, ELISA examination of patients' sera for anti-filaria IgG antibodies was performed.

conclusionsIn the CR, five cases of human dirofilariasis caused by Dirofilaria repens were recorded during 2010-2014 (species determination for three of them was confirmed besides morphological also by DNA analysis). At least, three of the cases were of autochthonous origin (the patients are Czech citizens residing in South Moravian Region who have never travelled abroad). The findings confirm the natural setting of D. repens in South Moravian Region of the CR. Dirofilariasis should be therefore considered as endemic in this area where it may represent a significant risk factor for public health.

Indexed as

AdolescentAdultAnimalsAntibodies, HelminthCzech RepublicDirofilaria repensDirofilariasisDNA, HelminthEnzyme-Linked Immunosorbent AssayHumansImmunoglobulin GMiddle AgedPolymerase Chain ReactionRNA, Ribosomal, 5SSkinSubcutaneous TissueAntibodies, HelminthDNA, HelminthImmunoglobulin GRNA, Ribosomal, 5SAutochthonous diseases in Czech RepublicDirofilaria repensEmerging diseaseHuman dirofilariasis

Identifiers

PMID27094256
PMCPMC4837637
OpenAlexW2336011221

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.