Evidence map›Paper›PMID 27094236›Full record

ArticleThe Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases

Clinical and microbiological implications of invasive pneumococcal disease in hospitalized patients (1998-2013).

Marta Inês Cazentini Medeiros, Bento Vidal de Moura Negrini, Jorgete Maria E Silva, Samanta Cristine Grassi Almeida, Maria Luiza Leopoldo, Maria Luiza Leopoldo Silva Guerra, Silva Guerra, Denise de Andrade

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Marta Inês Cazentini MedeirosRegional Laboratory Center VI, Instituto Adolfo Lutz, Ribeirão Preto, SP, Brazil. Electronic address: micmedeiros@ial.sp.gov.br.
Bento Vidal de Moura NegriniHospital Center of Epidemiology, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Jorgete Maria E SilvaHospital Center of Epidemiology, Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo (USP), Ribeirão Preto, SP, Brazil.
Samanta Cristine Grassi AlmeidaCenter of Bacteriology, Instituto Adolfo Lutz, São Paulo, SP, Brazil.
Maria Luiza LeopoldoCenter of Bacteriology, Instituto Adolfo Lutz, São Paulo, SP, Brazil.
Maria Luiza Leopoldo Silva Guerra
Silva Guerra *Center of Bacteriology, Instituto Adolfo Lutz, São Paulo, SP, Brazil.
Denise de AndradeEscola de Enfermagem de Ribeirão Preto, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Instituto Adolfo Lutz · BRClinics Hospital of Ribeirão Preto · BRUniversidade de Ribeirão Preto · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInfections caused by Streptococcus pneumoniae (pneumococcus) still represent a challenge for health systems around the world.

objectiveThe objective of this study was to assess microbiological and clinical aspects in hospitalized patients with invasive pneumococcus disease between 1998 and 2013. MATERIALS AND

methodsThis was a retrospective study that analyzed the results of pneumococcus identification, serotyping, and susceptibility testing found in the Adolfo Lutz Institute databank. Personal variables, medical history and clinical outcome of patients admitted with invasive pneumococcal disease were analyzed. These were obtained from records of a public teaching hospital - Hospital das Clínicas Faculdade de Medicina Ribeirão Preto.

resultsThe sample comprised 332 patients. Patient age ranged from less than one month to 89 years old (mean 20.3 years) and the sample was predominately male. Pneumonia (67.8%) was the most common disease, accounting for 18.2% of deaths. Serotypes 14, 1, 3, 9V, 6B, 6A, 23F, 19A, 18C, 19F, 12F, and 4 were the most common (75.3%). Most patients, or 67.5%, were cured without any complication (success), 6.9% had some type of sequela (failure), and 25.6% died (failure). In the case of deaths due to meningitis, strains of fully penicillin resistant pneumococcus were isolated. Furthermore, 68.2% of patients who died presented some type of comorbidity. The 60 and older age group presented the most significant association (Odds Ratio=4.2), with outcome failure regardless of the presence of comorbidity. Serotype 18C was the most significant risk factor both in raw analysis (Odds Ratio=3.8) and when adjusted for comorbidity (Odds Ratio=5.0) or age (Odds Ratio=5.4). The same occurred with serotype 12F (respectively, Odds Ratio=5.1, Odds Ratio=5.0, and Odds Ratio=4.7)

conclusionThe present findings highlight the importance of IPD among young adults and older adults. In the era of conjugate vaccines, monitoring serotypes in different age groups is essential to assess the impact and adequacy of immunization.

Indexed as

AdolescentAdultAgedAged, 80 and overAge DistributionAnti-Bacterial AgentsBrazilChildChild, PreschoolFemaleHospitalizationHumansInfantMaleMiddle AgedPneumococcal InfectionsAnti-Bacterial AgentsVaccines, ConjugateComorbidityDeathSerotypesStreptococcus pneumoniae

Identifiers

PMID27094236
PMCPMC9425451
OpenAlexW2338683572

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.