Evidence map›Paper›PMID 27094232›Full record

ArticleJournal of cardiovascular electrophysiology2016

Wide QRS-T Angle on the 12-Lead ECG as a Predictor of Sudden Death Beyond the LV Ejection Fraction.

Kelvin C M Chua, Carmen Teodorescu, Kyndaron Reinier, Audrey Uy-Evanado, Aapo L Aro, Sandeep G Nair, Harpriya Chugh, Jonathan Jui, Sumeet S Chugh

Open access · greenAbstract read
In one paragraph

Article in Journal of cardiovascular electrophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
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  4. The Relationship between the Frontal QRS-T Angle on ECG and Physical Activity Level in Young Adults.International journal of environmental research and public health · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Kelvin C M ChuaHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Carmen TeodorescuHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kyndaron ReinierHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Audrey Uy-EvanadoHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Aapo L AroHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Sandeep G NairHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Harpriya ChughHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Jonathan JuiDepartments of Pathology and Emergency Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Sumeet S ChughHeart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Cedars-Sinai Medical Center · USOregon Health & Science University · US

Funding

Sudden Cardiac Death with Preserved Left Ventricular Ejection FractionR01HL126938 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHUGH, SUMEET S. · 2016 to 2019
$2.6M
Sudden Cardiac Death in Middle AgeR01HL122492 · NHLBI · CEDARS-SINAI MEDICAL CENTER · PI CHUGH, SUMEET S. · 2015 to 2018
$2.2M
NHLBI NIH HHS R01 HL122492NHLBI NIH HHS R01 HL126938
6 · The paper itself

Abstract

introductionImprovements in risk stratification for sudden cardiac arrest (SCA) will require discovery of markers that extend beyond the LV ejection fraction (LVEF). The frontal QRS-T angle has been shown to predict risk of SCA but the value of this marker independent of the LVEF has not been investigated. METHODS AND

resultsCases of adult SCA with an archived electrocardiogram (12-lead ECG) available before the event, with a computable frontal QRS-T angle, were identified from the Oregon Sudden Unexpected Death Study (Oregon SUDS) ongoing in the Portland, Oregon metro area. A total of 666 SCA cases (mean age 67.2 years; 95% CI, 52.3-82.1 years; 68.6% males) were compared to 863 controls (mean age 66.6 years, 55.2-78.0 years; 68.1% males; 75.0% had CAD) from the same geographical region. The mean frontal QRS-T angle was wider in cases (74(o) ; 95% CI, 17(o) -131(o) ) compared to controls (51(o) ; 95% CI, 5(o) -97(o;) P< 0.0001). A frontal QRS-T angle of more than 90(o) remained associated with increased risk of SCD after adjusting for age, gender, heart rate, prolonged intraventricular conduction, electrocardiographic left ventricular hypertrophy (ECG LVH), baseline comorbidities, and left ventricular ejection fraction (LVEF) (OR 2.2; 95% CI, 1.60-3.09; P< 0.0001).

conclusionA wide QRS-T angle greater than 90(o) is associated with an increased risk of SCA independent of the left ventricular ejection fraction.

Indexed as

Action PotentialsElectrocardiographyStroke VolumeVentricular Function, LeftAgedAged, 80 and overArrhythmias, CardiacCase-Control StudiesChi-Square DistributionDeath, Sudden, CardiacFemaleHeart RateHumansLogistic ModelsMaleMiddle AgedelectrocardiogramQRS-T anglesudden cardiac arrestsudden death

Identifiers

PMID27094232
PMCPMC5039018
OpenAlexW2338876735

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.