ArticleEuropean archives of psychiatry and clinical neuroscience2016
Regional differences in the expression of brain-derived neurotrophic factor (BDNF) pro-peptide, proBDNF and preproBDNF in the brain confer stress resilience.
Article in European archives of psychiatry and clinical neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Multisystemic Consequences of Brain-Derived Neurotrophic Factor (BDNF) Haploinsufficiency in the SD-BDNFtm1sage Rat Model.International journal of molecular sciences · 2026Review
- Chlorogenic Acid as a Neuroprotective Agent: Enhancing Plasticity and Promoting Brain Health and Functional Reserve.CNS & neurological disorders drug targets · 2026Article
- Potential associated factors of postoperative neurocognitive dysfunction in elderly patients: precursor of BDNF and mature BDNF in serum.Aging clinical and experimental research · 2025Article
- Implications of neurogenesis in depression through BDNF: rodent models, regulatory pathways, gut microbiota, and potential therapy.Molecular psychiatry · 2025Review
- Hippocampal exosomes from stroke aggravate post-stroke depression by regulating the expression of proBDNF and p75NTR and altering spine density.Scientific reports · 2024Article
- The role of brain-derived neurotrophic factor and its recombinant pro-isoforms in depressive disorder: Open questions.Biotechnology notes (Amsterdam, Netherlands) · 2024Article
- Isoalantolactone relieves depression-like behaviors in mice after chronic social defeat stress via the gut-brain axis.Psychopharmacology · 2023Article
- Exploring Rosiglitazone's Potential to Treat Alzheimer's Disease through the Modulation of Brain-Derived Neurotrophic Factor.Biology · 2023Review
- Influence of gut microbiota on resilience and its possible mechanisms.International journal of biological sciences · 2023Review
- New Frontiers in Neurodegeneration and Regeneration Associated with Brain-Derived Neurotrophic Factor and the rs6265 Single Nucleotide Polymorphism.International journal of molecular sciences · 2022Review
- Sulforaphane activates anti-inflammatory microglia, modulating stress resilience associated with BDNF transcription.Acta pharmacologica Sinica · 2022Article
- proBDNF expression induces apoptosis and inhibits synaptic regeneration by regulating the RhoA-JNK pathway in an in vitro post-stroke depression model.Translational psychiatry · 2021Article
- Stress-Related Dysfunction of Adult Hippocampal Neurogenesis-An Attempt for Understanding Resilience?International journal of molecular sciences · 2021Review
- Activation of BDNF by transcription factor Nrf2 contributes to antidepressant-like actions in rodents.Translational psychiatry · 2021Article
- The stress susceptibility factor FKBP51 controls S-ketamine-evoked release of mBDNF in the prefrontal cortex of mice.Neurobiology of stress · 2020Article
- Corticosterone Induced the Increase of proBDNF in Primary Hippocampal Neurons Via Endoplasmic Reticulum Stress.Neurotoxicity research · 2020Article
- The implication of BDNF Val66Met polymorphism in progression from subjective cognitive decline to mild cognitive impairment and Alzheimer's disease: a 9-year follow-up study.European archives of psychiatry and clinical neuroscience · 2020Article
- Brain-derived neurotrophic factor-TrkB signaling in the medial prefrontal cortex plays a role in the anhedonia-like phenotype after spared nerve injury.European archives of psychiatry and clinical neuroscience · 2020Article
- Development and Reorganization of Orientation Representation in the Cat Visual Cortex: Experience-Dependent Synaptic Rewiring in Early Life.Frontiers in neuroinformatics · 2020Article
- Platelets Selectively Regulate the Release of BDNF, But Not That of Its Precursor Protein, proBDNF.Frontiers in immunology · 2020Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using learned helplessness (LH) model of depression, we measured protein expression of brain-derived neurotrophic factor (BDNF) pro-peptide, BDNF precursors (proBDNF and preproBDNF) in the brain regions of LH (susceptible) and non-LH rats (resilience). Expression of preproBDNF, proBDNF and BDNF pro-peptide in the medial prefrontal cortex of LH rats, but not non-LH rats, was significantly higher than control rats, although expression of these proteins in the nucleus accumbens of LH rats was significantly lower than control rats. This study suggests that regional differences in conversion of BDNF precursors into BDNF and BDNF pro-peptide by proteolytic cleavage may contribute to stress resilience.
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