ReviewJournal of neural transmission (Vienna, Austria : 1996)2016
Long-range dysconnectivity in frontal and midline structures is associated to psychosis in 22q11.2 deletion syndrome.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- A Comprehensive Analysis of Cerebellar Volumes in the 22q11.2 Deletion Syndrome.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2023Article
- Abnormal nodal and global network organization in resting state functional MRI from subjects with the 22q11 deletion syndrome.Scientific reports · 2021Article
- Structural control energy of resting-state functional brain states reveals less cost-effective brain dynamics in psychosis vulnerability.Human brain mapping · 2021Article
- Identifying neurodevelopmental anomalies of white matter microstructure associated with high risk for psychosis in 22q11.2DS.Translational psychiatry · 2020Article
- Abnormalities in white matter tracts in the fronto-striatal-thalamic circuit are associated with verbal performance in 22q11.2DS.Schizophrenia research · 2020Article
- Electrophysiological network alterations in adults with copy number variants associated with high neurodevelopmental risk.Translational psychiatry · 2020Article
- Understanding the pediatric psychiatric phenotype of 22q11.2 deletion syndrome.American journal of medical genetics. Part A · 2018Review
- Article
- Frontal dysconnectivity in 22q11.2 deletion syndrome: an atlas-based functional connectivity analysis.Behavioral and brain functions : BBF · 2018Article
- Development of Structural Covariance From Childhood to Adolescence: A Longitudinal Study in 22q11.2DS.Frontiers in neuroscience · 2018Article
- A Mini Review on the Contribution of the Anterior Cingulate Cortex in the Risk of Psychosis in 22q11.2 Deletion Syndrome.Frontiers in psychiatry · 2018Review
- Functional Anatomy of the Inferior Longitudinal Fasciculus: From Historical Reports to Current Hypotheses.Frontiers in neuroanatomy · 2018Review
- White matter microstructural deficits in 22q11.2 deletion syndrome.Psychiatry research. Neuroimaging · 2017Article
- Article
- Multimodal investigation of triple network connectivity in patients with 22q11DS and association with executive functions.Human brain mapping · 2017Article
- The social brain network in 22q11.2 deletion syndrome: a diffusion tensor imaging study.Behavioral and brain functions : BBF · 2017Article
- Machine-learning classification of 22q11.2 deletion syndrome: A diffusion tensor imaging study.NeuroImage. Clinical · 2017Article
- Altered structural network architecture is predictive of the presence of psychotic symptoms in patients with 22q11.2 deletion syndrome.NeuroImage. Clinical · 2017Article
- Quantifying indices of short- and long-range white matter connectivity at each cortical vertex.PloS one · 2017Article
- Disrupted anatomic networks in the 22q11.2 deletion syndrome.NeuroImage. Clinical · 2016Article
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4 authors.
Funding
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Abstract
Patients affected by 22q11.2 deletion syndrome (22q11DS) present a characteristic cognitive and psychiatric profile and have a genetic predisposition to develop schizophrenia. Although brain morphological alterations have been shown in the syndrome, they do not entirely account for the complex clinical picture of the patients with 22q11DS and for their high risk of psychotic symptoms. Since Friston proposed the "disconnection hypothesis" in 1998, schizophrenia is commonly considered as a disorder of brain connectivity. In this study, we review existing evidence pointing to altered brain structural and functional connectivity in 22q11DS, with a specific focus on the role of dysconnectivity in the emergence of psychotic symptoms. We show that widespread alterations of structural and functional connectivity have been described in association with 22q11DS. Moreover, alterations involving long-range association tracts as well as midline structures, such as the corpus callosum and the cingulate gyrus, have been associated with psychotic symptoms in this population. These results suggest common mechanisms for schizophrenia in syndromic and non-syndromic populations. Future directions for investigations are also discussed.
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