ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
Evaluation of ECG-gated [(11)C]acetate PET for measuring left ventricular volumes, mass, and myocardial external efficiency.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Cardiovascular Effects of Treatment With the Ketone Body 3-Hydroxybutyrate in Chronic Heart Failure Patients.Circulation · 2019Trial
- Effects of DAPAgliflozin on CARDiac substrate uptake, myocardial efficiency, and myocardial contractile work in type 2 diabetes patients-a description of the DAPACARD study.Upsala journal of medical sciences · 2019Trial
- Quantitation of mitral regurgitation using positron emission tomography.EJNMMI research · 2024Article
- Repeatable and reproducible measurements of myocardial oxidative metabolism, blood flow and external efficiency usingJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Automatic calculation of myocardial external efficiency using a singleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Tight software, methodological/physiological variation, less so.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Test-retest repeatability of myocardial oxidative metabolism and efficiency using standalone dynamicJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2018Article
- Myocardial Oxygen Consumption and Efficiency in Patients With Cardiac Amyloidosis.Journal of the American Heart Association · 2018Article
- Myocardial Oxygen Consumption and Efficiency in Aortic Valve Stenosis Patients With and Without Heart Failure.Journal of the American Heart Association · 2017Article
Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNoninvasive estimation of myocardial external efficiency (MEE) requires measurements of left ventricular (LV) oxygen consumption with [(11)C]acetate PET in addition to LV stroke volume and mass with cardiovascular magnetic resonance (CMR). Measuring LV geometry directly from ECG-gated [(11)C]acetate PET might enable MEE evaluation from a single PET scan. Therefore, we sought to establish the accuracy of measuring LV volumes, mass, and MEE directly from ECG-gated [(11)C]acetate PET.
methodsThirty-five subjects with aortic valve stenosis underwent ECG-gated [(11)C]acetate PET and CMR. List mode PET data were rebinned into 16-bin ECG-gated uptake images before measuring LV volumes and mass using commercial software and compared to CMR. Dynamic datasets were used for calculation of mean LV oxygen consumption and MEE.
resultsLV mass, volumes, and ejection fraction measured by CMR and PET correlated strongly (r = 0.86-0.92, P < .001 for all), but were underestimated by PET (P < .001 for all except ESV P = .79). PET-based MEE, corrected for bias, correlated fairly with PET/CMR-based MEE (r = 0.60, P < .001, bias -3 ± 21%, P = .56). PET-based MEE bias was strongly associated with LV wall thickness.
conclusionsAlthough analysis-related improvements in accuracy are recommended, LV geometry estimated from ECG-gated [(11)C]acetate PET correlate excellently with CMR and can indeed be used to evaluate MEE.
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