Trial reportTrials2016
Stress ulcer prophylaxis with a proton pump inhibitor versus placebo in critically ill patients (SUP-ICU trial): study protocol for a randomised controlled trial.
Trial report in Trials, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02467621 (Stress Ulcer Prophylaxis in the Intensive Care Unit), which is not on this map. Cited by 18 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU)
Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 53 citations in OpenAlex.
- Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units.The Cochrane database of systematic reviews · 2018Pooled it
- Stress ulcer prophylaxis in intensive care unit patients receiving enteral nutrition: a systematic review and meta-analysis.Critical care (London, England) · 2018Pooled it
- Effect sizes in ongoing randomized controlled critical care trials.Critical care (London, England) · 2017Pooled it
- Article
- Efficient treatment of esophageal nutrition bezoars: dissolution outmatches removal-the Zurich approach.Clinical journal of gastroenterology · 2021Article
- Heterogeneity of treatment effect of prophylactic pantoprazole in adult ICU patients: a post hoc analysis of the SUP-ICU trial.Intensive care medicine · 2020Article
- Audit on Practices of Stress Ulcer Prophylaxis in Intensive Care Unit Patients.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2020Article
- Pantoprazole prophylaxis in ICU patients with high severity of disease: a post hoc analysis of the placebo-controlled SUP-ICU trial.Intensive care medicine · 2019Article
- Is research from databases reliable? No.Intensive care medicine · 2019Article
- Stress Ulcer Prophylaxis in Neurocritical Care.Neurocritical care · 2018Review
- Focus on fluid therapy and nutritional support.Intensive care medicine · 2018Article
- Complications and Pharmacologic Interventions of Invasive Positive Pressure Ventilation During Critical Illness.The Journal of pharmacy technology : jPT : official publication of the Association of Pharmacy Technicians · 2018Review
- Clinical impact of upper gastrointestinal endoscopy in critically ill patients with suspected bleeding.Annals of intensive care · 2018Article
- Article
- Do we still need pharmacological stress ulcer prophylaxis at the ICU?Journal of thoracic disease · 2017Article
- What's new with stress ulcer prophylaxis in the ICU?Intensive care medicine · 2017Review
- Observational
- Should We Continue to Use Stress Ulcer Prophylaxis for Critically Ill Patients?The Canadian journal of hospital pharmacyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 6 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCritically ill patients in the intensive care unit (ICU) are at risk of clinically important gastrointestinal bleeding, and acid suppressants are frequently used prophylactically. However, stress ulcer prophylaxis may increase the risk of serious adverse events and, additionally, the quantity and quality of evidence supporting the use of stress ulcer prophylaxis is low. The aim of the SUP-ICU trial is to assess the benefits and harms of stress ulcer prophylaxis with a proton pump inhibitor in adult patients in the ICU. We hypothesise that stress ulcer prophylaxis reduces the rate of gastrointestinal bleeding, but increases rates of nosocomial infections and myocardial ischaemia. The overall effect on mortality is unpredictable. METHODS/
designThe SUP-ICU trial is an investigator-initiated, pragmatic, international, multicentre, randomised, blinded, parallel-group trial of stress ulcer prophylaxis with a proton pump inhibitor versus placebo (saline) in 3350 acutely ill ICU patients at risk of gastrointestinal bleeding. The primary outcome measure is 90-day mortality. Secondary outcomes include the proportion of patients with clinically important gastrointestinal bleeding, pneumonia, Clostridium difficile infection or myocardial ischaemia, days alive without life support in the 90-day period, serious adverse reactions, 1-year mortality, and health economic analyses. The sample size will enable us to detect a 20 % relative risk difference (5 % absolute risk difference) in 90-day mortality assuming a 25 % event rate with a risk of type I error of 5 % and power of 90 %. The trial will be externally monitored according to Good Clinical Practice standards. Interim analyses will be performed after 1650 and 2500 patients.
conclusionThe SUP-ICU trial will provide high-quality data on the benefits and harms of stress ulcer prophylaxis with a proton pump inhibitor in critically ill adult patients admitted in the ICU.
trial registrationClinicalTrials.gov Identifier: NCT02467621 .
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.