ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2017
Mifepristone Reduces Food Palatability and Affects Drosophila Feeding and Lifespan.
Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
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- Insulin/insulin-like growth factor signaling pathway promotes higher fat storage inbioRxiv : the preprint server for biology · 2025Article
- Pharmacology of Aging:Aging biology · 2024Article
- Conditional Inhibition of Eip75B Eliminates the Effects of Mating and Mifepristone on Lifespan in FemaleCells · 2024Article
- A neuron-glia lipid metabolic cycle couples daily sleep to mitochondrial homeostasis.Nature neuroscience · 2024Article
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- Use of Farnesyl Transferase Inhibitors in an Ageing Model inJournal of developmental biology · 2023Article
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- Spatial control of gene expression in flies using bacterially derived binary transactivation systems.Insect molecular biology · 2021Article
- Activation of innate immunity during development induces unresolved dysbiotic inflammatory gut and shortens lifespan.Disease models & mechanisms · 2021Article
- Metabolic Signatures of Life Span Regulated by Mating, Sex Peptide, and Mifepristone/RU486 in Female Drosophila melanogaster.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Absolute ethanol intake predicts ethanol preference inThe Journal of experimental biology · 2020Article
- Effects of unpaired 1 gene overexpression on the lifespan of Drosophila melanogaster.BMC systems biology · 2019Article
- Tissue-specific alteration of gene expression and function by RU486 and the GeneSwitch system.NPJ aging and mechanisms of disease · 2019Article
- Measurement of solid food intake in Drosophila via consumption-excretion of a dye tracer.Scientific reports · 2018Article
- TheBiology open · 2018Article
- Article
- The 4E-BP growth pathway regulates the effect of ambient temperature onProceedings of the National Academy of Sciences of the United States of America · 2017Article
- Mifepristone/RU486 acts in Drosophila melanogaster females to counteract the life span-shortening and pro-inflammatory effects of male Sex Peptide.Biogerontology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The Drosophila GeneSwitch system facilitates the spatial and temporal control of gene expression through dietary supplementation of mifepristone (RU486). Because experimental and control groups differ only by treatment with RU486, confounding results from using flies of different genetic backgrounds are eliminated, making GeneSwitch especially useful in studies of aging. However, the effect of RU486 itself on longevity has not been well characterized, particularly in relation to nutritional states known to affect lifespan. Here, we show that RU486 has dose- and diet-dependent effects on longevity in both sexes. On low nutrient diets, RU486 supplementation reduces total food consumption, perhaps exacerbating undernutrition to shorten life. RU486 also inhibits proboscis extension responses to low nutrient diets, suggesting that RU486 has an aversive taste which leads to decreased food consumption and diminished longevity. RU486 is not detrimental to fly lifespan on high nutrient food, correlating with reduced effects of the drug on palatability and total consumption on rich diets. Our results highlight the critical importance of considering how food palatability and nutrient intake might be altered by dietary or drug manipulations in studies of aging and behavior.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.