ArticleMenopause (New York, N.Y.)2016
The association between high-sensitivity C-reactive protein and hypertension in women of the CARDIA study.
Article in Menopause (New York, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Effects of concurrent training on body composition, metabolic, and inflammatory in postmenopausal women: a meta-analysis.BMC women's health · 2026Pooled it
- Residential green space, walkability, and cardiometabolic biomarkers in midlife women: a longitudinal cohort study.Environmental research, health : ERH · 2026Article
- G.A study protocol for a randomized controlled trial investigating the influence of Iyengar Yoga on biofunctional age and cardiovascular risk associated biomarker of postmenopausal women.Frontiers in global women's health · 2026Article
- The crucial role of hypertension in determining latent classes of metabolic syndrome in northern Iran and predictive power of these classes in non-alcoholic fatty liver: a gender-based insight.Frontiers in endocrinology · 2025Article
- Temporal Relationship Between Visceral Fat and Inflammation, and Their Joint Effect on Cardiometabolic Diseases: Evidence from the China Health and Retirement Longitudinal Study (CHARLS).Journal of inflammation research · 2025Article
- The Role of Curcumin in Modulating Vascular Function and Structure during Menopause: A Systematic Review.Biomedicines · 2024Review
- Characterizing the spectrum of bladder health and lower urinary tract symptoms among men: Results from the CARDIA study.Neurourology and urodynamics · 2024Article
- Women's Reproductive Milestones and Cardiovascular Disease Risk: A Review of Reports and Opportunities From the CARDIA Study.Journal of the American Heart Association · 2023Review
- Article
- Cardiovascular Health Trajectories and Elevated C-Reactive Protein: The CARDIA Study.Journal of the American Heart Association · 2021Article
- White blood cell count and incidence of hypertension in the general Japanese population: ISSA-CKD study.PloS one · 2021Article
- Serum Ischemia-Modified Albumin, Fibrinogen, High Sensitivity C- Reactive Proteins in Type-2 Diabetes Mellitus without Hypertension and Diabetes Mellitus with Hypertension: A Case-Control Study.Reports of biochemistry & molecular biology · 2020Article
- The association between high-sensitivity C-reactive protein and blood pressure in Yi people.BMC public health · 2019Article
- A cross-sectional study on serum high-sensitivity C-reactive protein level and shift work among reproductive age women.Caspian journal of internal medicine · 2019Article
- The association between mean platelet volume and inflammation in geriatric patients with emergency hypertension.Turkish journal of emergency medicine · 2019Article
- Successful treatment of obesity and insulin resistance via ketogenic diet status post Roux-en-Y.BMJ case reports · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectiveThe aim of this study was to determine the prevalence of hypertension in midlife women, characterize the association between high-sensitivity C-reactive protein (hs-CRP) and hypertension in women, and describe differences in hypertension prevalence by menopausal stage.
methodsWe included 1,625 women, aged 43 to 55 years, with measurements of hs-CRP and detailed reproductive histories in the Coronary Artery Risk Development in Young Adults study at follow-up year 25. Prevalent hypertension was defined as a systolic blood pressure of 140 mm Hg, or diastolic blood pressure of 90 mm Hg or greater, or use of antihypertensive medications. Logistic regression was used for analysis.
resultsThe prevalence of hypertension was 25.8%, 37.8%, and 39.0% in premenopausal, perimenopausal, and postmenopausal women, respectively. The median (25th and 75th percentiles) of hs-CRP was 3.08 (1.12, 7.98) μg/mL and 1.18 (0.48, 3.15) μg/mL in women with and without hypertension, respectively. After adjusting for confounders, metabolic factors and body mass index, a doubling (100% increment) in hs-CRP levels was significantly associated with hypertension in premenopausal (1.27 [1.01-1.59]), but not in perimenopausal (1.12 [0.99-1.27]) or postmenopausal (1.09 [0.95-1.26]) women.
conclusionsHypertension was common in midlife women. The association of hs-CRP and hypertension was consistent across menopausal stages. The association of hs-CRP with hypertension was independent of body mass index in premenopausal but not in perimenopausal or postmenopausal women.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.