Evidence map›Paper›PMID 27093473›Full record

ReviewCritical reviews in biotechnology2017

Advances in Candida detection platforms for clinical and point-of-care applications.

Mohammadali Safavieh, Chad Coarsey, Nwadiuto Esiobu, Adnan Memic, Jatin Mahesh Vyas, Hadi Shafiee, Waseem Asghar

Open access · greenAbstract readReview
In one paragraph

Review in Critical reviews in biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.

  1. Nucleic Acid Amplification Tests forPathogens (Basel, Switzerland) · 2026
    Pooled it
  2. Article
  3. Article
  4. Antifungal Susceptibility Profile ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2025
    Article
  5. Article
  6. Article
  7. Article
  8. Treatment Practices for Adults With Candidemia at 9 Active Surveillance Sites-United States, 2017-2018.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  9. Review
  10. Article
  11. Molecular identification ofCurrent medical mycology · 2021
    Article
  12. Review
  13. Biosensors and Diagnostics for Fungal Detection.Journal of fungi (Basel, Switzerland) · 2020
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Review
  20. Direct Detection ofSensors (Basel, Switzerland) · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Mohammadali Safavieha Division of Biomedical Engineering, Division of Renal medicine, Department of Medicine , Brigham and Women's Hospital, Harvard Medical School , Cambridge , MA , USA.
Chad Coarseyb Department of Computer Engineering and Electrical Engineering and Computer Science , Florida Atlantic University , Boca Raton , FL , USA.
Nwadiuto Esiobud Biological Sciences Department , Florida Atlantic University , Davie , FL , USA.
Adnan Memice Center of Nanotechnology, King Abdulaziz University , Jeddah , Saudi Arabia.
Jatin Mahesh Vyasf Department of Medicine, Division of Infectious Disease , Massachusetts General Hospital , Boston , MA , USA.
Hadi Shafieea Division of Biomedical Engineering, Division of Renal medicine, Department of Medicine , Brigham and Women's Hospital, Harvard Medical School , Cambridge , MA , USA.
Waseem Asgharb Department of Computer Engineering and Electrical Engineering and Computer Science , Florida Atlantic University , Boca Raton , FL , USA.
Florida Atlantic University · USBrigham and Women's Hospital · USKing Abdulaziz University · SAMassachusetts General Hospital · US

Funding

Sensitive and quantitative point-of-care viral load testing on paperR01AI118502 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2016 to 2020
$2.2M
Functional Role of the Tetraspanin CD82/Kai1 in Innate and Adaptive ImmunityR01AI092084 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI VYAS, JATIN M · 2011 to 2015
$2.2M
Development of disposable and refrigeration-free microchip technology for CD4+ T cell counting at point-of-care settingsR15AI127214 · NIAID · FLORIDA ATLANTIC UNIVERSITY · PI ASGHAR, WASEEM · 2016 to 2016
$460k
Label-free HIV-1 Viral Load Measurement through a Contactless Electrode MicrochipF32AI102590 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI SHAFIEE, HADI · 2013 to 2015
$171k
NIAID NIH HHS F32 AI102590NIAID NIH HHS R01 AI092084NIAID NIH HHS R01 AI118502NIAID NIH HHS R15 AI127214
6 · The paper itself

Abstract

Invasive candidiasis remains one of the most serious community and healthcare-acquired infections worldwide. Conventional Candida detection methods based on blood and plate culture are time-consuming and require at least 2-4 days to identify various Candida species. Despite considerable advances for candidiasis detection, the development of simple, compact and portable point-of-care diagnostics for rapid and precise testing that automatically performs cell lysis, nucleic acid extraction, purification and detection still remains a challenge. Here, we systematically review most prominent conventional and nonconventional techniques for the detection of various Candida species, including Candida staining, blood culture, serological testing and nucleic acid-based analysis. We also discuss the most advanced lab on a chip devices for candida detection.

Indexed as

Candida albicansCandidiasisCross InfectionHumansLab-On-A-Chip DevicesPoint-of-Care SystemsPoint-of-Care TestingBlood culturedisease diagnosticsinvasive Candidiasislaboratory on a chiploop-mediated isothermal amplificationmicrofluidicsnanotechnology

Identifiers

PMID27093473
PMCPMC5083221
OpenAlexW2336043212

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.