ArticlePloS one2016
Bidirectional Association between Asthma and Irritable Bowel Syndrome: Two Population-Based Retrospective Cohort Studies.
Article in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Immune activation in irritable bowel syndrome: what is the evidence?Nature reviews. Immunology · 2022Review
- Risk Factors for Self-reported Irritable Bowel Syndrome With Prior Psychiatric Disorder: The Lifelines Cohort Study.Journal of neurogastroenterology and motility · 2022Article
- Probiotics: Protecting Our Health from the Gut.Microorganisms · 2022Review
- Asthma and the risk of gastrointestinal disorders: a Mendelian randomization study.BMC medicine · 2022Article
- Preliminary development of a questionnaire to measure the extra-pulmonary symptoms of severe asthma.BMC pulmonary medicine · 2021Article
- Allergy-related diseases in childhood and risk for abdominal pain-related functional gastrointestinal disorders at 16 years-a birth cohort study.BMC medicine · 2021Article
- Mast Cell Activation Syndrome: A Primer for the Gastroenterologist.Digestive diseases and sciences · 2021Review
- Irritable bowel syndrome increases the risk of chronic obstructive pulmonary disease: A retrospective cohort study.Scientific reports · 2020Article
- Association between functional abdominal pain disorders and asthma in adolescents: A cross-sectional study.World journal of clinical cases · 2018Article
- Irritable bowel syndrome in children: Current knowledge, challenges and opportunities.World journal of gastroenterology · 2018Review
- Risk of developing pleural empyema in patients with stroke: a propensity-matched cohort study.Internal and emergency medicine · 2017Article
- Patients with uterine leiomyoma exhibit a high incidence but low mortality rate for breast cancer.Oncotarget · 2017Article
- Possible therapeutic role of IgE blockade in irritable bowel syndrome.World journal of gastroenterology · 2016Article
- Association between irritable bowel syndrome and asthma: a meta-analysis and systematic review.Annals of gastroenterologyArticle
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a demonstrated association between asthma and irritable bowel syndrome (IBS). In this study, we examined the bidirectional association between asthma and IBS using a nationwide database.
methodsWe conducted two retrospective cohort studies using data obtained from the National Health Insurance of Taiwan. Study 1 included 29,648 asthma patients newly diagnosed between 2000 and 2010. Study 2 included 29,875 IBS patient newly diagnosed between 2000 and 2010. For each study, four subjects without asthma and IBS were selected, respectively, frequency-matched by sex, age, and the diagnosis date. All four cohorts were followed up until the end of 2011 to estimate incident IBS for Study 1 and incident asthma for study 2. Adjusted hazard ratios (aHRs) were estimated using the Cox proportional hazards model after controlling for sex, age and comorbidities.
resultsThe incidence of IBS was 1.89 times higher in the asthma cohort than in the comparison cohort (8.26 vs. 4.36 per 1,000 person-years), with an aHR of 1.57 [95% confidence interval (CI) = 1.47-1.68]. The aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities. In contrast, the incidence of asthma was 1.76 times higher in the IBS cohort than the comparison cohort (7.09 vs. 4.03 per 1,000 person-years), with an aHR of 1.54 (95% CI = 1.44-1.64). Similarly, aHRs remained significant in all subgroups measured by sex, age and the presence of comorbidities.
conclusionThe present study suggests a bidirectional association between asthma and IBS. Atopy could be a shared pathophysiology underlying this association, deserving a further investigation.
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