Evidence map›Paper›PMID 27093085›Full record

ArticleDevelopmental cell2016

Calmodulin Promotes N-BAR Domain-Mediated Membrane Constriction and Endocytosis.

Margaret D Myers, Sergey Ryazantsev, Linda Hicke, Gregory S Payne

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.3field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
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  5. CaFrontiers in molecular neuroscience · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Margaret D MyersDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Sergey RyazantsevDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Linda HickeMolecular Genetics and Microbiology, College of Natural Sciences, University of Texas at Austin, Austin, TX 78712, USA.
Gregory S PayneDepartment of Biological Chemistry, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA. Electronic address: gpayne@mednet.ucla.edu.
University of California, Los Angeles · USThe University of Texas at Austin · US

Funding

MOLECULAR STUDIES OF SELECTIVE PROTEIN TRANSPORTR01GM039040 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PAYNE, GREGORY S · 1988 to 2016
$6.4M
Mechanism and function of ubiquitin binding by conserved endocytic protein Rvs167F32GM085921 · NIGMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MYERS, MARGARET · 2008 to 2011
$156k
NIGMS NIH HHS 1F32GM085921NIGMS NIH HHS F32 GM085921NIGMS NIH HHS GM39040NIGMS NIH HHS R01 GM039040
6 · The paper itself

Abstract

Membrane remodeling by BAR (Bin, Amphiphysin, RVS) domain-containing proteins, such as endophilins and amphiphysins, is integral to the process of endocytosis. However, little is known about the regulation of endocytic BAR domain activity. We have identified an interaction between the yeast Rvs167 N-BAR domain and calmodulin. Calmodulin-binding mutants of Rvs167 exhibited defects in endocytic vesicle release. In vitro, calmodulin enhanced membrane tubulation and constriction by wild-type Rvs167 but not calmodulin-binding-defective mutants. A subset of mammalian N-BAR domains bound calmodulin, and co-expression of calmodulin with endophilin A2 potentiated tubulation in vivo. These studies reveal a conserved role for calmodulin in regulating the intrinsic membrane-sculpting activity of endocytic N-BAR domains.

Indexed as

AnimalsCalmodulinCell MembraneConstrictionEndocytosisLiposomesMicrofilament ProteinsNerve Tissue ProteinsProtein BindingProtein Structure, TertiarySaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsamphiphysinCalmodulinLiposomesMicrofilament ProteinsNerve Tissue ProteinsRVS167 protein, S cerevisiaeSaccharomyces cerevisiae Proteins

Identifiers

PMID27093085
PMCPMC4855880
OpenAlexW2340489874

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.