ArticleDevelopmental cell2016
Scaling Pattern to Variations in Size during Development of the Vertebrate Neural Tube.
Article in Developmental cell, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 47 citations in OpenAlex.
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- Morphogens in the evolution of size, shape and patterning.Development (Cambridge, England) · 2024Review
- Precise and scalable self-organization in mammalian pseudo-embryos.Nature structural & molecular biology · 2024Article
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- Expression atlas of avian neural crest proteins: Neurulation to migration.Developmental biology · 2022Article
- Actuation enhances patterning in human neural tube organoids.Nature communications · 2021Article
- Regulation of size and scale in vertebrate spinal cord development.Wiley interdisciplinary reviews. Developmental biology · 2021Review
- Complex crosstalk of Notch and Hedgehog signalling during the development of the central nervous system.Cellular and molecular life sciences : CMLS · 2021Review
- Coordination between patterning and morphogenesis ensures robustness during mouse development.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Step-wise evolution of neural patterning by Hedgehog signalling in chordates.Nature ecology & evolution · 2020Article
- Natural size variation among embryos leads to the corresponding scaling in gene expression.Developmental biology · 2020Article
- A model of neocortical area patterning in the lissencephalic mouse may hold for larger gyrencephalic brains.The Journal of comparative neurology · 2019Article
- Scale invariance of BMP signaling gradients in zebrafish.Scientific reports · 2019Article
- Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.Nature communications · 2018Article
- Scale-invariant patterning by size-dependent inhibition of Nodal signalling.Nature cell biology · 2018Article
- Neural crest and the origin of species-specific pattern.Genesis (New York, N.Y. : 2000) · 2018Review
- Morphogen gradient reconstitution reveals Hedgehog pathway design principles.Science (New York, N.Y.) · 2018Article
- Divergent axial morphogenesis and earlyEvoDevo · 2018Article
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6 authors at 2 institutions in 2 countries.
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Abstract
Anatomical proportions are robustly maintained in individuals that vary enormously in size, both within a species and between members of related taxa. However, the mechanisms underlying scaling are still poorly understood. We have examined this phenomenon in the context of the patterning of the ventral neural tube in response to a gradient of the morphogen Sonic hedgehog (SHH) in the chick and zebra finch, two species that differ in size during the time of neural tube patterning. We find that scaling is achieved, at least in part, by altering the sensitivity of the target cells to SHH and appears to be achieved by modulating the ratio of the repressive and activating transcriptional regulators, GLI2 and GLI3. This mechanism contrasts with previous experimental and theoretical analyses of morphogenic scaling that have focused on compensatory changes in the morphogen gradient itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.