ArticleTranslational psychiatry2016
Dimensions of depressive symptoms and cingulate volumes in older adults.
Article in Translational psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Structural Neuroimaging Correlates of Neuropsychiatric Symptoms in Alzheimer's Disease: A Systematic Literature Review.Dementia and geriatric cognitive disorders · 2025Pooled it
- Depression and Cognitive Control across the Lifespan: a Systematic Review and Meta-Analysis.Neuropsychology review · 2020Pooled it
- Brain Regional Predictors of Surgical Response Are Dynamically Associated with Post-Surgical Pain Relief in Trigeminal Neuralgia.Brain sciences · 2026Article
- The impact of glioblastoma on the contralesional hemisphere: insights from structural connectivity and cortical surface analysis.Neuroradiology · 2025Article
- Disrupted small-world architecture and altered default mode network topology of brain functional network in college students with subclinical depression.BMC psychiatry · 2025Article
- Distinct effect of partial sleep deprivation associated with gray matter changes in young and old adults.Frontiers in aging neuroscience · 2025Article
- Change in Depressive Symptoms and Longitudinal Regional Amyloid Accumulation in Unimpaired Older Adults.JAMA network open · 2024Article
- Structural connectivity changes in unilateral hearing loss.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Research on adults with subthreshold depression after aerobic exercise: a resting-state fMRI study based on regional homogeneity (ReHo).Frontiers in neuroscience · 2024Article
- Neuroplasticity of the white matter tracts underlying recovery of diarrhea-predominant irritable bowel syndrome following acupuncture treatment.Frontiers in neuroscience · 2024Article
- The bidirectional effects between cognitive ability and brain morphology: A life course Mendelian randomization analysis.medRxiv : the preprint server for health sciences · 2023Article
- Sleep Traits Causally Affect the Brain Cortical Structure: A Mendelian Randomization Study.Biomedicines · 2023Article
- Life After Mild Traumatic Brain Injury: Widespread Structural Brain Changes Associated With Psychological Distress Revealed With Multimodal Magnetic Resonance Imaging.Biological psychiatry global open science · 2023Article
- Neurobiological and genetic correlates of the dissociative subtype of posttraumatic stress disorder.Journal of psychopathology and clinical science · 2023Article
- Neuroanatomical Correlates of the Late Positive Potential in Youth with Pediatric Bipolar Disorder.Current neuropharmacology · 2023Article
- Depressive Symptoms in Older Adults via Multimodal Markers on Magnetic Resonance Imaging: A Literature Review.JAR life · 2023Article
- The web of laughter: frontal and limbic projections of the anterior cingulate cortex revealed by cortico-cortical evoked potential from sites eliciting laughter.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Dissociable neural mechanisms of cognition and well-being in youth versus healthy aging.Psychology and aging · 2022Article
- Orbitofrontal and Cingulate Thickness Asymmetry Associated with Depressive Symptom Dimensions.Cognitive, affective & behavioral neuroscience · 2021Article
- Psychopathological Syndromes Across Affective and Psychotic Disorders Correlate With Gray Matter Volumes.Schizophrenia bulletin · 2021Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Clinical depression and subthreshold depressive symptoms in older adults have been linked to structural changes in the cingulate gyrus. The cingulate comprises functionally distinct subregions that may have distinct associations with different types, or symptom dimensions, of depression. This study examined the relationship between symptom dimensions of depression and gray matter volumes in the anterior cingulate, posterior cingulate and isthmus of the cingulate in a nonclinical sample. The study included 41 community-dwelling older adults between the ages of 55 and 81. Participants received a structural magnetic resonance imaging scan and completed the Center for Epidemiologic Studies Depression Scale. Subscale scores for depressed mood, somatic symptoms and lack of positive affect were calculated, and Freesurfer was used to extract cingulate gray matter volumes. Regression analyses were conducted to examine the relationship between depressive symptoms and volumes of cingulate subregions while controlling for sex, age and estimated total intracranial volume. Higher scores on the depressed mood subscale were associated with larger volumes in the left posterior cingulate and smaller volumes in the isthmus cingulate. Higher scores on the somatic symptoms subscale were significantly related to smaller volumes in the posterior cingulate. A trend was observed for a positive relationship between higher scores on the lack of positive affect subscale and larger volumes in the anterior cingulate cortex. These results are consistent with previous findings of altered cingulate volumes with increased depressive symptomatology and suggest specific symptom dimensions of depression may differ in their relationship with subregions of the cingulate.
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