ArticlePLoS computational biology2016
Hippocampal CA1 Ripples as Inhibitory Transients.
Article in PLoS computational biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 59 citations in OpenAlex.
- Article
- Cholinergic modulation of neural networks supports sequential and complementary roles for NREM and REM states in memory consolidation.PLoS computational biology · 2025Article
- Differences in the consolidation by spontaneous and evoked ripples in the presence of active dendrites.PLoS computational biology · 2024Article
- Single closed-loop acoustic stimulation targeting memory consolidation suppressed hippocampal ripple and thalamo-cortical spindle activity in mice.The European journal of neuroscience · 2024Article
- Intra-ripple frequency accommodation in an inhibitory network model for hippocampal ripple oscillations.PLoS computational biology · 2024Article
- A developmental increase of inhibition promotes the emergence of hippocampal ripples.Nature communications · 2024Article
- Article
- Hippocampal non-theta state: The "Janus face" of information processing.Frontiers in neural circuits · 2023Review
- Interneuronal network model of theta-nested fast oscillations predicts differential effects of heterogeneity, gap junctions and short term depression for hyperpolarizing versus shunting inhibition.PLoS computational biology · 2022Article
- Hippocampal replays appear after a single experience and incorporate greater detail with more experience.Neuron · 2022Article
- High-frequency oscillations and sequence generation in two-population models of hippocampal region CA1.PLoS computational biology · 2022Article
- Neuregulin 1 and ErbB4 Kinase Actively Regulate Sharp Wave Ripples in the Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Sequential Attractors in Combinatorial Threshold-Linear Networks.SIAM journal on applied dynamical systems · 2022Article
- Stress enhances hippocampal neuronal synchrony and alters ripple-spike interaction.Neurobiology of stress · 2021Article
- Gating of hippocampal rhythms and memory by synaptic plasticity in inhibitory interneurons.Neuron · 2021Article
- Bidirectional Interaction of Hippocampal Ripples and Cortical Slow Waves Leads to Coordinated Spiking Activity During NREM Sleep.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- NMDA receptors promote hippocampal sharp-wave ripples and the associated coactivity of CA1 pyramidal cells.Hippocampus · 2020Article
- Mechanisms of neural organization and rhythmogenesis during hippocampal and cortical ripples.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- A model of cholinergic suppression of hippocampal ripples through disruption of balanced excitation/inhibition.Hippocampus · 2019Article
- Large time step discrete-time modeling of sharp wave activity in hippocampal area CA3.Communications in nonlinear science & numerical simulation · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Memories are stored and consolidated as a result of a dialogue between the hippocampus and cortex during sleep. Neurons active during behavior reactivate in both structures during sleep, in conjunction with characteristic brain oscillations that may form the neural substrate of memory consolidation. In the hippocampus, replay occurs within sharp wave-ripples: short bouts of high-frequency activity in area CA1 caused by excitatory activation from area CA3. In this work, we develop a computational model of ripple generation, motivated by in vivo rat data showing that ripples have a broad frequency distribution, exponential inter-arrival times and yet highly non-variable durations. Our study predicts that ripples are not persistent oscillations but result from a transient network behavior, induced by input from CA3, in which the high frequency synchronous firing of perisomatic interneurons does not depend on the time scale of synaptic inhibition. We found that noise-induced loss of synchrony among CA1 interneurons dynamically constrains individual ripple duration. Our study proposes a novel mechanism of hippocampal ripple generation consistent with a broad range of experimental data, and highlights the role of noise in regulating the duration of input-driven oscillatory spiking in an inhibitory network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.