Evidence map›Paper›PMID 27092866›Full record

ReviewCurrent opinion in cell biology2016

Mechanisms of polarity protein expression control.

Syed Mukhtar Ahmed, Ian G Macara

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Review
  3. Transcriptional Control of Apical-Basal Polarity Regulators.International journal of molecular sciences · 2021
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Syed Mukhtar AhmedDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA.
Ian G MacaraDepartment of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37240, USA. Electronic address: Ian.g.macara@vanderbilt.edu.

Funding

Cancer and ContextR35CA197571 · NCI · VANDERBILT UNIVERSITY · PI MACARA, IAN G · 2015 to 2021
$6.7M
MECHANISMS OF CELL POLARITY ESTABLISHMENTR01GM070902 · NIGMS · VANDERBILT UNIVERSITY · PI MACARA, IAN G · 2004 to 2022
$5.4M
NCI NIH HHS R35 CA197571NIGMS NIH HHS R01 GM070902
6 · The paper itself

Abstract

Polarity is a universal feature of cells during division and often at other stages of the cell cycle or after post-mitotic differentiation. A conserved machinery, present in all animals, initiates and maintains polarity. Multi-cellular animals organize themselves with respect to the axes of symmetry of the organism through the process of planar cell polarity, but many tissues also express a cell-intrinsic form of polarity, for instance to segregate the apical and basolateral membranes of epithelial cells. Although the genes and proteins involved in apical-basal polarity have been known for many years, the regulation of their expression remains ill-defined. Maintenance of the correct expression levels is essential for normal cell lineage allocation, tissue morphogenesis and cell survival. Here we summarize what is known about the transcriptional and post-transcriptional regulation of polarity protein expression, and discuss areas that remain to be understood.

Indexed as

Cell PolarityGene Expression RegulationAnimalsEpithelial-Mesenchymal TransitionHumansProteinsProteolysisVirusesProteins

Identifiers

PMID27092866
PMCPMC5064826

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.