ArticlePLoS neglected tropical diseases2016
Analysis on Gene Expression Profile in Oncospheres and Early Stage Metacestodes from Echinococcus multilocularis.
Article in PLoS neglected tropical diseases, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 38 citations in OpenAlex.
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- Identification and characterization of the elusive protein backbone of the immuno-dominant and species-specific Em2(G11) metacestode antigen ofFrontiers in parasitology · 2025Article
- Current status and future prospects ofVeterinary and animal science · 2024Review
- Genome-wide transcriptome analysis ofFrontiers in cellular and infection microbiology · 2024Article
- Targeted and non-targeted proteomics to characterize the parasite proteins ofFrontiers in cellular and infection microbiology · 2023Article
- Function of lipid binding proteins of parasitic helminths: still a long road.Parasitology research · 2022Review
- Cestodes in the genomic era.Parasitology research · 2022Review
- Transcriptional effects of electroporation on Echinococcus multilocularis primary cell culture.Parasitology research · 2022Article
- Screening, construction, and serological identification of the diagnostic antigen molecule EG-06283 for the diagnosis of Echinococcus granulosus.Parasitology research · 2021Article
- Comparative Transcriptome Analyses of the Developmental Stages ofFrontiers in veterinary science · 2021Article
- Application of target repositioning and in silico screening to exploit fatty acid binding proteins (FABPs) from Echinococcus multilocularis as possible drug targets.Journal of computer-aided molecular design · 2020Article
- Transcriptomic Analysis of the Early Strobilar Development ofPathogens (Basel, Switzerland) · 2020Article
- Knowledge, attitudes and practices regarding echinococcosis in Xizang Autonomous Region, China.BMC public health · 2020Article
- Fatty acid-binding proteins in Echinococcus spp.: the family has grown.Parasitology research · 2020Article
- Histone deacetylase enzymes as potential drug targets of Neglected Tropical Diseases caused by cestodes.International journal for parasitology. Drugs and drug resistance · 2019Article
- Three-dimensional hepatocyte culture system for the study of Echinococcus multilocularis larval development.PLoS neglected tropical diseases · 2018Article
- Functional diversity of secreted cestode Kunitz proteins: Inhibition of serine peptidases and blockade of cation channels.PLoS pathogens · 2017Article
- Genome-Wide Transcriptome Analysis Reveals Extensive Alternative Splicing Events in the Protoscoleces ofFrontiers in microbiology · 2017Article
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar echinococcosis is a worldwide zoonosis of great public health concern. Analysis of genome data for Echinococcus multilocularis has identified antigen families that can be used in diagnostic assays and vaccine development. However, little gene expression data is available for antigens of the egg and early larval stages. To address this information gap, we used a Next-Generation Sequencing approach to investigate three different stages (non-activated and activated oncospheres, and early stage metacestodes) of E. multilocularis (Nemuro strain). Transcriptome data analysis revealed that some diagnostic antigen gp50 isoforms and the antigen Eg95 family dominated in activated oncospheres, and the antigen B family dominated in early stage metacestodes. Furthermore, heat shock proteins and antigen II/3 are constantly expressed in the three stages. The expression pattern of various known antigens in E. multilocularis may give fundamental information for choosing candidate genes used in diagnosis and vaccine development.
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