ArticleJournal of toxicology and environmental health. Part A2016
Impacts of prenatal nanomaterial exposure on male adult Sprague-Dawley rat behavior and cognition.
Article in Journal of toxicology and environmental health. Part A, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
16 citing papers in PubMed, 43 citations in OpenAlex.
- Persistent impact of in utero nanoparticle exposure on metabolic and endocrine outcomes in adult rats fed a high-fat diet.Reproductive toxicology (Elmsford, N.Y.) · 2026Article
- In Utero Nano-Titanium Dioxide Exposure Results in Sexually Dimorphic Weight Gain and Cardiovascular Function in Offspring.Cardiovascular toxicology · 2025Article
- Distinct profiles of oxylipid mediators in liver, lung, and placenta after maternal nano-TiOEnvironmental science. Advances · 2023Article
- Neurotoxicity of Titanium Dioxide Nanoparticles: A Comprehensive Review.International journal of nanomedicine · 2023Review
- Chronic maternal exposure to titanium dioxide nanoparticles alters breathing in newborn offspring.Particle and fibre toxicology · 2022Article
- Development of coronary dysfunction in adult progeny after maternal engineered nanomaterial inhalation during gestation.Scientific reports · 2021Article
- Nephroblastoma in a Sprague Dawley rat unrelated to titanium dioxide nanoparticle exposure in utero.Veterinary medicine and science · 2021Article
- Fetotoxicity of Nanoparticles: Causes and Mechanisms.Nanomaterials (Basel, Switzerland) · 2021Review
- Nanopolystyrene translocation and fetal deposition after acute lung exposure during late-stage pregnancy.Particle and fibre toxicology · 2020Article
- Identification and quantification of gold engineered nanomaterials and impaired fluid transfer across the rat placenta via ex vivo perfusion.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2019Article
- Particle toxicology and health - where are we?Particle and fibre toxicology · 2019Review
- Maternal titanium dioxide nanomaterial inhalation exposure compromises placental hemodynamics.Toxicology and applied pharmacology · 2019Article
- Group II innate lymphoid cells and microvascular dysfunction from pulmonary titanium dioxide nanoparticle exposure.Particle and fibre toxicology · 2018Article
- Prenatal exposure to TiOTranslational psychiatry · 2018Article
- Engineered nanomaterial applications in perinatal therapeutics.Pharmacological research · 2018Review
- Maternal engineered nanomaterial inhalation during gestation alters the fetal transcriptome.Particle and fibre toxicology · 2018Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
It is generally accepted that gestational xenobiotic exposures result in systemic consequences in the adult F1 generation. However, data on detailed behavioral and cognitive consequences remain limited. Using our whole-body nanoparticle inhalation facility, pregnant Sprague-Dawley rats (gestational day [GD] 7) were exposed 4 d/wk to either filtered air (control) or nano-titanium dioxide aerosols (nano-TiO2; count median aerodynamic diameter of 170.9 ± 6.4 nm, 10.4 ± 0.4 mg/m(3), 5 h/d) for 7.8 ± 0.5 d of the remaining gestational period. All rats received their final exposure on GD 20 prior to delivery. The calculated daily maternal deposition was 13.9 ± 0.5 µg. Subsequently, at 5 mo of age, behavior and cognitive functions of these pups were evaluated employing a standard battery of locomotion, learning, and anxiety tests. These assessments revealed significant working impairments, especially under maximal mnemonic challenge, and possible deficits in initial motivation in male F1 adults. Evidence indicates that maternal engineered nanomaterial exposure during gestation produces psychological deficits that persist into adulthood in male rats.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.