ArticleeNeuro
Transition from Target to Gaze Coding in Primate Frontal Eye Field during Memory Delay and Memory-Motor Transformation.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Drifting population dynamics with transient resets characterize sensorimotor transformation in the monkey superior colliculus.Communications biology · 2026Article
- Article
- Integration of landmark and saccade target signals in macaque frontal cortex visual responses.Communications biology · 2023Article
- Integration of allocentric and egocentric visual information in a convolutional/multilayer perceptron network model of goal-directed gaze shifts.Cerebral cortex communications · 2022Article
- Errors in visuospatial working memory across space and time.Scientific reports · 2021Article
- Compensating for a shifting world: evolving reference frames of visual and auditory signals across three multimodal brain areas.Journal of neurophysiology · 2021Article
- Across-Area Synchronization Supports Feature Integration in a Biophysical Network Model of Working Memory.Frontiers in neural circuits · 2021Article
- Dynamic shifts of visual and saccadic signals in prefrontal cortical regions 8Ar and FEF.Journal of neurophysiology · 2020Article
- Interplay between persistent activity and activity-silent dynamics in the prefrontal cortex underlies serial biases in working memory.Nature neuroscience · 2020Article
- Spatiotemporal transformations for gaze control.Physiological reports · 2020Review
- Nonretinocentric localization of successively presented flashes during smooth pursuit eye movements.Journal of vision · 2020Article
- From Prior Information to Saccade Selection: Evolution of Frontal Eye Field Activity during Natural Scene Search.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Eye-head-hand coordination during visually guided reaches in head-unrestrained macaques.Journal of neurophysiology · 2019Article
- Selective Changes in Noise Correlations Contribute to an Enhanced Representation of Saccadic Targets in Prefrontal Neuronal Ensembles.Cerebral cortex (New York, N.Y. : 1991) · 2018Article
- Beyond the labeled line: variation in visual reference frames from intraparietal cortex to frontal eye fields and the superior colliculus.Journal of neurophysiology · 2018Article
- The Influence of a Memory Delay on Spatial Coding in the Superior Colliculus: Is Visual Always Visual and Motor Always Motor?Frontiers in neural circuits · 2018Article
- Cortical Activation during Landmark-Centered vs. Gaze-Centered Memory of Saccade Targets in the Human: An FMRI Study.Frontiers in systems neuroscience · 2017Article
- Decoding Target Distance and Saccade Amplitude from Population Activity in the Macaque Lateral Intraparietal Area (LIP).Frontiers in integrative neuroscience · 2016Article
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5 authors.
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Abstract
The frontal eye fields (FEFs) participate in both working memory and sensorimotor transformations for saccades, but their role in integrating these functions through time remains unclear. Here, we tracked FEF spatial codes through time using a novel analytic method applied to the classic memory-delay saccade task. Three-dimensional recordings of head-unrestrained gaze shifts were made in two monkeys trained to make gaze shifts toward briefly flashed targets after a variable delay (450-1500 ms). A preliminary analysis of visual and motor response fields in 74 FEF neurons eliminated most potential models for spatial coding at the neuron population level, as in our previous study (Sajad et al., 2015). We then focused on the spatiotemporal transition from an eye-centered target code (T; preferred in the visual response) to an eye-centered intended gaze position code (G; preferred in the movement response) during the memory delay interval. We treated neural population codes as a continuous spatiotemporal variable by dividing the space spanning T and G into intermediate T-G models and dividing the task into discrete steps through time. We found that FEF delay activity, especially in visuomovement cells, progressively transitions from T through intermediate T-G codes that approach, but do not reach, G. This was followed by a final discrete transition from these intermediate T-G delay codes to a "pure" G code in movement cells without delay activity. These results demonstrate that FEF activity undergoes a series of sensory-memory-motor transformations, including a dynamically evolving spatial memory signal and an imperfect memory-to-motor transformation.
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