Evidence map›Paper›PMID 27092144›Full record

ArticleFrontiers in immunology2016

Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection.

Maja Arapović, Ilija Brizić, Branka Popović, Slaven Jurković, Stefan Jordan, Astrid Krmpotić, Jurica Arapović, Stipan Jonjić

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Maja ArapovićDepartment of Histology and Embryology, Faculty of Medicine, University of Rijeka , Rijeka , Croatia.
Ilija BrizićCenter for Proteomics, Faculty of Medicine, University of Rijeka , Rijeka , Croatia.
Branka PopovićDepartment of Histology and Embryology, Faculty of Medicine, University of Rijeka , Rijeka , Croatia.
Slaven JurkovićDepartment of Medical Physics, Clinical Hospital Rijeka , Rijeka , Croatia.
Stefan JordanDepartment of Oncological Sciences, Tisch Cancer Institute and the Immunology Institute, Icahn School of Medicine at Mount Sinai , New York, NY , USA.
Astrid KrmpotićDepartment of Histology and Embryology, Faculty of Medicine, University of Rijeka , Rijeka , Croatia.
Jurica ArapovićDepartment of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia; Faculty of Medicine, University of Mostar, Mostar, Bosnia and Herzegovina.
Stipan JonjićDepartment of Histology and Embryology, Faculty of Medicine, University of Rijeka, Rijeka, Croatia; Center for Proteomics, Faculty of Medicine, University of Rijeka, Rijeka, Croatia.
University of Rijeka · HRIcahn School of Medicine at Mount Sinai · US

Funding

European Research Council 322693
6 · The paper itself

Abstract

In addition to their role as effector cells in virus control, natural killer (NK) cells have an immunoregulatory function in shaping the antiviral T-cell response. This function is further pronounced in perforin-deficient mice that show the enhanced NK-cell proliferation and cytokine secretion upon mouse cytomegalovirus (MCMV) infection. Here, we confirmed that stronger activation and maturation of NK cells in perforin-deficient mice correlates with higher MCMV load. To further characterize the immunoregulatory potential of perforin, we compared the response of NK cells that express or do not express perforin using bone-marrow chimeras. Our results demonstrated that the enhanced proliferation and maturation of NK cells in MCMV-infected bone-marrow chimeras is an intrinsic property of perforin-deficient NK cells. Thus, in addition to confirming that NK-cell proliferation is virus load dependent, our data extend this notion demonstrating that perforin plays an intrinsic role as a feedback mechanism in the regulation of NK-cell proliferation during viral infections.

Indexed as

bone-marrow chimeraLy49Hm157mouse cytomegalovirusNK cellsperforinproliferation

Identifiers

PMID27092144
PMCPMC4822405
OpenAlexW2322067534

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.