ArticleFrontiers in computational neuroscience2016
Disinhibition-Induced Delayed Onset of Epileptic Spike-Wave Discharges in a Five Variable Model of Cortex and Thalamus.
Article in Frontiers in computational neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed.
- Analysis of Epilepsy Treatment Strategies Based on an Astrocyte-Neuron-Coupled Network Model.Brain sciences · 2025Article
- Alpha rhythm slowing in a modified thalamo-cortico-thalamic model related with Alzheimer's disease.PloS one · 2020Article
- Dynamic Transitions of Epilepsy Waveforms Induced by Astrocyte Dysfunction and Electrical Stimulation.Neural plasticity · 2020Article
- Robust closed-loop control of spike-and-wave discharges in a thalamocortical computational model of absence epilepsy.Scientific reports · 2019Article
- Control of Absence Seizures by the Thalamic Feed-Forward Inhibition.Frontiers in computational neuroscience · 2017Article
- Combined Effects of Feedforward Inhibition and Excitation in Thalamocortical Circuit on the Transitions of Epileptic Seizures.Frontiers in computational neuroscience · 2017Article
- Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach.Frontiers in computational neuroscience · 2017Article
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3 authors.
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Abstract
Based on a modified neural field network model composed of cortex and thalamus, we here propose a computational framework to investigate the onset control of absence seizure, which is characterized by the spike-wave discharges. Firstly, we briefly demonstrate the existence of various transition types in Taylor's model by increasing the thalamic input. Furthermore, after the disinhibitory function is reasonably introduced into the Taylor's model, we can observe the occurrence of various transition states of firing patterns with different dominant frequencies as the thalamic input is varied under different disinhibitory effects onto the pyramidal neural population. Interestingly, it is found that the onset of spike-wave discharges can be delayed as the disinhibitory input is considered. More importantly, we explore bifurcation mechanism of firing transitions as some key parameters are changed. And also, we observe other dynamical states, such as simple oscillations and saturated discharges with different spatial scales, which are consistent with previous theoretical or experimental findings.
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