Evidence map›Paper›PMID 27092033›Full record

ReviewEXCLI journal2013

Three dimensional electron microscopy and in silico tools for macromolecular structure determination.

Subhomoi Borkotoky, Chetan Kumar Meena, Mohammad Wahab Khan, Ayaluru Murali

Abstract readReview
In one paragraph

Review in EXCLI journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Subhomoi BorkotokyCentre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry-605014, India.
Chetan Kumar MeenaCentre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry-605014, India.
Mohammad Wahab KhanCentre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry-605014, India.
Ayaluru MuraliCentre for Bioinformatics, School of Life Sciences, Pondicherry University, Puducherry-605014, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, structural biology witnessed a major tool - electron microscopy - in solving the structures of macromolecules in addition to the conventional techniques, X-ray crystallography and nuclear magnetic resonance (NMR). Three dimensional transmission electron microscopy (3DTEM) is one of the most sophisticated techniques for structure determination of molecular machines. Known to give the 3-dimensional structures in its native form with literally no upper limit on size of the macromolecule, this tool does not need the crystallization of the protein. Combining the 3DTEM data with in silico tools, one can have better refined structure of a desired complex. In this review we are discussing about the recent advancements in three dimensional electron microscopy and tools associated with it.

Indexed as

cryo-EMCTF correctionsegmentationsingle particle analysis

Identifiers

PMID27092033
PMCPMC4827587

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.