ArticleProceedings of the National Academy of Sciences of the United States of America2016
Gene duplication confers enhanced expression of 27-kDa γ-zein for endosperm modification in quality protein maize.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.
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45 citing papers in PubMed, 82 citations in OpenAlex.
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- Breeding for colored quality protein popcorn with improved amino acid composition.Frontiers in plant science · 2026Article
- Decades' progress and prospects on maize functional genomics and molecular breeding.Science China. Life sciences · 2025Review
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- Combined Genome-Wide Association Study and Linkage Analysis for Mining Candidate Genes for the Kernel Row Number in Maize (Plants (Basel, Switzerland) · 2024Article
- Biparental graph strategy to represent and analyze hybrid plant genomes.Plant physiology · 2024Article
- Genome-wide association study of carotenoids in maize kernel.The plant genome · 2024Article
- Genome-wide association study of trace elements in maize kernels.BMC plant biology · 2024Article
- Editing the 19 kDa alpha-zein gene family generates non-opaque2-based quality protein maize.Plant biotechnology journal · 2024Article
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- Genome-wide association study of kernel colour traits and mining of elite alleles from the major loci in maize.BMC plant biology · 2024Article
- Genetic dissection of maize (Zea maysL.) trace element traits using genome-wide association studies.BMC plant biology · 2023Article
- A genome-wide association study identifies a transporter for zinc uploading to maize kernels.EMBO reports · 2023Article
- Nitrogen-dependent binding of the transcription factor PBF1 contributes to the balance of protein and carbohydrate storage in maize endosperm.The Plant cell · 2023Article
- Genetic and molecular understanding for the development of methionine-rich maize: a holistic approach.Frontiers in plant science · 2023Review
- Tandem duplicate expression patterns are conserved between maize haplotypes of thePlant direct · 2021Article
- Miniature Seed6, encoding an endoplasmic reticulum signal peptidase, is critical in seed development.Plant physiology · 2021Article
- Expression profile of protein fractions in the developing kernel of normal, Opaque-2 and quality protein maize.Scientific reports · 2021Article
- Final Selection of Quality Protein Popcorn Hybrids.Frontiers in plant science · 2021Article
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Authors and funding
18 authors at 8 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
The maize opaque2 (o2) mutant has a high nutritional value but it develops a chalky endosperm that limits its practical use. Genetic selection for o2 modifiers can convert the normally chalky endosperm of the mutant into a hard, vitreous phenotype, yielding what is known as quality protein maize (QPM). Previous studies have shown that enhanced expression of 27-kDa γ-zein in QPM is essential for endosperm modification. Taking advantage of genome-wide association study analysis of a natural population, linkage mapping analysis of a recombinant inbred line population, and map-based cloning, we identified a quantitative trait locus (qγ27) affecting expression of 27-kDa γ-zein. qγ27 was mapped to the same region as the major o2 modifier (o2 modifier1) on chromosome 7 near the 27-kDa γ-zein locus. qγ27 resulted from a 15.26-kb duplication at the 27-kDa γ-zein locus, which increases the level of gene expression. This duplication occurred before maize domestication; however, the gene structure of qγ27 appears to be unstable and the DNA rearrangement frequently occurs at this locus. Because enhanced expression of 27-kDa γ-zein is critical for endosperm modification in QPM, qγ27 is expected to be under artificial selection. This discovery provides a useful molecular marker that can be used to accelerate QPM breeding.
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