ArticleProceedings of the National Academy of Sciences of the United States of America2016
Dynamics of prebiotic RNA reproduction illuminated by chemical game theory.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Population-dependent agent performance in non-transitive games: a multi-agent rock-paper-scissors benchmark.Scientific reports · 2026Article
- Multispecies autocatalytic RNA reaction networks in coacervates.Communications chemistry · 2023Article
- A Mutation Threshold for Cooperative Takeover.Life (Basel, Switzerland) · 2022Article
- Self-Reproduction and Darwinian Evolution in Autocatalytic Chemical Reaction Systems.Life (Basel, Switzerland) · 2021Review
- Darwinian properties and their trade-offs in autocatalytic RNA reaction networks.Nature communications · 2021Article
- From self-replication to replicator systems en route to de novo life.Nature reviews. Chemistry · 2020Review
- Coupled catabolism and anabolism in autocatalytic RNA sets.Nucleic acids research · 2018Article
- Origin of biomolecular games: deception and molecular evolution.Journal of the Royal Society, Interface · 2018Article
- Chemical Transformations in Proto-Cytoplasmic Media. Phosphorus Coupling in the Silica Hydrogel Phase.Life (Basel, Switzerland) · 2017Article
- Prebiotic RNA Network Formation: A Taxonomy of Molecular Cooperation.Life (Basel, Switzerland) · 2017Article
- Extinction rates in tumour public goods games.Journal of the Royal Society, Interface · 2017Article
- Topological and thermodynamic factors that influence the evolution of small networks of catalytic RNA species.RNA (New York, N.Y.) · 2017Article
- Group I Intron Internal Guide Sequence Binding Strength as a Component of Ribozyme Network Formation.Molecules (Basel, Switzerland) · 2016Article
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5 authors.
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Abstract
Many origins-of-life scenarios depict a situation in which there are common and potentially scarce resources needed by molecules that compete for survival and reproduction. The dynamics of RNA assembly in a complex mixture of sequences is a frequency-dependent process and mimics such scenarios. By synthesizing Azoarcus ribozyme genotypes that differ in their single-nucleotide interactions with other genotypes, we can create molecules that interact among each other to reproduce. Pairwise interplays between RNAs involve both cooperation and selfishness, quantifiable in a 2 × 2 payoff matrix. We show that a simple model of differential equations based on chemical kinetics accurately predicts the outcomes of these molecular competitions using simple rate inputs into these matrices. In some cases, we find that mixtures of different RNAs reproduce much better than each RNA type alone, reflecting a molecular form of reciprocal cooperation. We also demonstrate that three RNA genotypes can stably coexist in a rock-paper-scissors analog. Our experiments suggest a new type of evolutionary game dynamics, called prelife game dynamics or chemical game dynamics. These operate without template-directed replication, illustrating how small networks of RNAs could have developed and evolved in an RNA world.
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